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Gene Review

VMA9  -  H(+)-transporting V0 sector ATPase subunit e

Saccharomyces cerevisiae S288c

Synonyms: CWH36, LDB10, Low dye-binding protein 10, V-ATPase subunit e, V-type proton ATPase subunit e, ...
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High impact information on VMA9

  • We demonstrate that disruption of yeast VMA9 results in the failure of V1 and V0 V-ATPase subunits to assemble onto the vacuole and in decreased levels of the subunit a isoforms Vph1p and Stv1p [1].
  • In the ER, Vma9p and the V0 subunits interact with the V-ATPase assembly factor Vma21p [1].
  • We also show that Vma9p is an integral membrane protein, synthesized and inserted into the endoplasmic reticulum (ER), which then localizes to the limiting membrane of the vacuole [1].
  • Vma9p is localized to the vacuole but fails to reach the vacuole in a mutant lacking one of the integral membrane subunits of the V-ATPase [2].
  • The open reading frame responsible for the Deltacwh36 phenotypes is YCL005W-A [3].

Biological context of VMA9

  • We demonstrate that disruption of YCL005W-A is entirely responsible for the Vma(-) growth phenotype of the cwh36Delta mutant [2].

Anatomical context of VMA9


Associations of VMA9 with chemical compounds

  • Deletion of the gene CWH36 resulted in a severe growth defect on iron-limited medium, as well as increased sensitivity to Congo red and calcofluor white [3].

Other interactions of VMA9

  • Interestingly, the association of Vma9p with the V0-Vma21p assembly complex is disrupted with the loss of any single V0 subunit [1].


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