The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Gene Review

prtP  -  pseudo

Treponema denticola ATCC 35405

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of prtP

 

High impact information on prtP

  • Mutagenesis of a novel gene in the prcA-prtP protease locus affects expression of Treponema denticola membrane complexes [1].
  • The open reading frame which codes for the 72-kDa protein was designated prtP [2].
  • The prtP gene of ATCC 35405 was inactivated by insertion of an erythromycin-resistance cassette, yielding mutant K1 [3].
  • These data confirm that inactivation of the prtP gene completely reverses T. denticola's disruption of epithelial junctions, but there are pleiotropic effects of the mutation that may account for its apparently diminished effects on the cytoskeleton of HGF when the cells were challenged with OM extracts [3].
 

Other interactions of prtP

  • Strains with mutations in either the prcA-prtP or the msp region showed altered expression of a product(s) of the other locus [1].
 

Analytical, diagnostic and therapeutic context of prtP

  • The results of real-time polymerase chain reaction suggested that prtP mRNA expression in the mutant was somewhat decreased compared with the wild-type strain [4].

References

  1. Mutagenesis of a novel gene in the prcA-prtP protease locus affects expression of Treponema denticola membrane complexes. Bian, X.L., Wang, H.T., Ning, Y., Lee, S.Y., Fenno, J.C. Infect. Immun. (2005) [Pubmed]
  2. Characterization of the Treponema denticola prtP gene encoding a prolyl-phenylalanine-specific protease (dentilisin). Ishihara, K., Miura, T., Kuramitsu, H.K., Okuda, K. Infect. Immun. (1996) [Pubmed]
  3. Insertional inactivation of the prtP gene of Treponema denticola confirms dentilisin's disruption of epithelial junctions. Ellen, R.P., Ko, K.S., Lo, C.M., Grove, D.A., Ishihara, K. J. Mol. Microbiol. Biotechnol. (2000) [Pubmed]
  4. A 43-kDa protein of Treponema denticola is essential for dentilisin activity. Ishihara, K., Kuramitsu, H.K., Okuda, K. FEMS Microbiol. Lett. (2004) [Pubmed]
 
WikiGenes - Universities