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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Trpa1  -  transient receptor potential cation...

Mus musculus

Synonyms: ANKTM1, Anktm1, Ankyrin-like with transmembrane domains protein 1, TRPA1b, Transient receptor potential cation channel subfamily A member 1
 
 
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High impact information on Trpa1

  • Here, we describe the characterization of ANKTM1, a cold-activated channel with a lower activation temperature compared to the cold and menthol receptor, TRPM8 [1].
  • Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol [1].
  • To test the in vivo roles of TRPA1, we generated a mouse in which the essential exons required for proper function of the Trpa1 gene were deleted [2].
  • We show that, in addition to noxious cold, pungent natural compounds present in cinnamon oil, wintergreen oil, clove oil, mustard oil, and ginger all activate TRPA1 (ANKTM1) [3].
  • Peptide map analysis indicated that the M75 light chain contained the IB-peptide marker, a V kappa polymorphism expressed by C.C58 but not BALB/c mice, which is determined by the IgK-Trpa allele present on chromosome 6 [4].

References

  1. ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Story, G.M., Peier, A.M., Reeve, A.J., Eid, S.R., Mosbacher, J., Hricik, T.R., Earley, T.J., Hergarden, A.C., Andersson, D.A., Hwang, S.W., McIntyre, P., Jegla, T., Bevan, S., Patapoutian, A. Cell (2003) [Pubmed]
  2. TRPA1 Contributes to Cold, Mechanical, and Chemical Nociception but Is Not Essential for Hair-Cell Transduction. Kwan, K.Y., Allchorne, A.J., Vollrath, M.A., Christensen, A.P., Zhang, D.S., Woolf, C.J., Corey, D.P. Neuron (2006) [Pubmed]
  3. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Bandell, M., Story, G.M., Hwang, S.W., Viswanath, V., Eid, S.R., Petrus, M.J., Earley, T.J., Patapoutian, A. Neuron (2004) [Pubmed]
  4. Unique V kappa group associated with two mouse L chain genetic markers. Gottlieb, P.D., Tsang, H.C., Gibson, D.M., Cannon, L.E. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
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