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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

lmaA  -  antigen A

Listeria monocytogenes serotype 4b str. F2365

 
 
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Disease relevance of lmaA

  • The lmaA gene of Listeria monocytogenes encodes a protein capable of inducing delayed-type hypersensitivity reactions in L. monocytogenes-immune mice (S. Göhmann, M. Leimeister-Wachter, E. Schiltz, W. Goebel, and T. Chakraborty, M. Microbiol. 4:1091-1099, 1990) [1].
 

High impact information on lmaA

  • Northern blot analysis of the lma operon showed that lmaA is expressed by two transcripts: the longer lmaDCBA transcript of 2,100 nucleotides, which was observed at growth temperatures of 37 and 20 degrees C, and a shorter transcript consisting of lmaBA, which is detected only at low temperatures (20 degrees C) [1].
  • While all IIIC and most IIIB isolates carry the putative virulence gene lmaA, the majority of subgroup IIIA isolates lack this gene [2].
 

Analytical, diagnostic and therapeutic context of lmaA

References

  1. Identification, cloning, and characterization of the Ima operon, whose gene products are unique to Listeria monocytogenes. Schäferkordt, S., Chakraborty, T. J. Bacteriol. (1997) [Pubmed]
  2. Genetic and phenotypic characterization of Listeria monocytogenes lineage III. Roberts, A., Nightingale, K., Jeffers, G., Fortes, E., Kongo, J.M., Wiedmann, M. Microbiology (Reading, Engl.) (2006) [Pubmed]
  3. Detection of genes coding for listeriolysin and Listeria monocytogenes antigen A (ImaA) in Listeria spp. by the polymerase chain reaction. Johnson, W.M., Tyler, S.D., Ewan, E.P., Ashton, F.E., Wang, G., Rozee, K.R. Microb. Pathog. (1992) [Pubmed]
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