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Gene Review:

M2 - M2-1

Human metapneumovirus

Biacchesi, S. et al., Dar, A.M. et al., Buchholz, U.J. et al., Jacobs, J.A. et al.

Buchholz, Biacchesi, Pham, Tran, Yang, Luongo, Skiadopoulos, Murphy, Collins,

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Disease relevance of M2

Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity [1].
Strictly conserved residues common to all members of the Pneumovirinae were identified in the predicted amino acid sequences of the P and M2 protein-predicted amino acid sequences [2].

High impact information on M2

Recombinant human metapneumovirus (HMPV) in which the SH, G, or M2 gene or open reading frame was deleted by reverse genetics was evaluated for replication and vaccine efficacy following topical administration to the respiratory tract of African green monkeys, a permissive primate host [3].
Each M2 mutant virus directed efficient multicycle growth in Vero cells [1].

Analytical, diagnostic and therapeutic context of M2

Limited heterogeneity was observed among the M2 sequences, suggesting that diagnostic tests and vaccines against APV C are likely to exhibit broad cross-reactivity [4].
Sequence analysis of the matrix (M2) protein gene of avian pneumovirus recovered from turkey flocks in the United States [4].

References

Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity. Buchholz, U.J., Biacchesi, S., Pham, Q.N., Tran, K.C., Yang, L., Luongo, C.L., Skiadopoulos, M.H., Murphy, B.R., Collins, P.L. J. Virol. (2005) [Pubmed]
Subtype B avian metapneumovirus resembles subtype A more closely than subtype C or human metapneumovirus with respect to the phosphoprotein, and second matrix and small hydrophobic proteins. Jacobs, J.A., Njenga, M.K., Alvarez, R., Mawditt, K., Britton, P., Cavanagh, D., Seal, B.S. Virus Res. (2003) [Pubmed]
Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. Biacchesi, S., Pham, Q.N., Skiadopoulos, M.H., Murphy, B.R., Collins, P.L., Buchholz, U.J. J. Virol. (2005) [Pubmed]
Sequence analysis of the matrix (M2) protein gene of avian pneumovirus recovered from turkey flocks in the United States. Dar, A.M., Munir, S., Goyal, S.M., Kapur, V. J. Clin. Microbiol. (2003) [Pubmed]

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