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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Metapneumovirus


High impact information on Metapneumovirus


Chemical compound and disease context of Metapneumovirus


Biological context of Metapneumovirus


Gene context of Metapneumovirus

  • Studies explore impact of new pathogens: investigators report on metapneumovirus, SARS [20].
  • Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment [21].
  • The genes encoding the putative small hydrophobic (SH), attachment (G) and polymerase (L) proteins of the Colorado isolate of subgroup C avian pneumovirus (APV) were entirely or partially sequenced [22].
  • In common with the M2 genes of the RS viruses and avian pneumovirus (APV), the PVM mRNA also contained a second ORF (ORF2) that partially overlaps the first ORF and which is capable of encoding a 98 residue polypeptide [23].
  • Based on the results obtained, human metapneumovirus infections in Madrid followed a seasonal pattern, with most of the infections occurring between February and April [19].

Analytical, diagnostic and therapeutic context of Metapneumovirus


  1. Effects of human metapneumovirus and respiratory syncytial virus antigen insertion in two 3' proximal genome positions of bovine/human parainfluenza virus type 3 on virus replication and immunogenicity. Tang, R.S., Schickli, J.H., MacPhail, M., Fernandes, F., Bicha, L., Spaete, J., Fouchier, R.A., Osterhaus, A.D., Spaete, R., Haller, A.A. J. Virol. (2003) [Pubmed]
  2. Sequence polymorphism of the predicted human metapneumovirus G glycoprotein. Peret, T.C., Abed, Y., Anderson, L.J., Erdman, D.D., Boivin, G. J. Gen. Virol. (2004) [Pubmed]
  3. Detection of antibodies to U.S. isolates of avian pneumovirus by a recombinant nucleocapsid protein-based sandwich enzyme-linked immunosorbent assay. Gulati, B.R., Munir, S., Patnayak, D.P., Goyal, S.M., Kapur, V. J. Clin. Microbiol. (2001) [Pubmed]
  4. Expression of recombinant small hydrophobic protein for serospecific detection of avian pneumovirus subgroup C. Luo, L., Sabara, M.I., Li, Y. Clin. Diagn. Lab. Immunol. (2005) [Pubmed]
  5. Infection of nonhuman primates with recombinant human metapneumovirus lacking the SH, G, or M2-2 protein categorizes each as a nonessential accessory protein and identifies vaccine candidates. Biacchesi, S., Pham, Q.N., Skiadopoulos, M.H., Murphy, B.R., Collins, P.L., Buchholz, U.J. J. Virol. (2005) [Pubmed]
  6. Deletion of M2 gene open reading frames 1 and 2 of human metapneumovirus: effects on RNA synthesis, attenuation, and immunogenicity. Buchholz, U.J., Biacchesi, S., Pham, Q.N., Tran, K.C., Yang, L., Luongo, C.L., Skiadopoulos, M.H., Murphy, B.R., Collins, P.L. J. Virol. (2005) [Pubmed]
  7. A wild goose metapneumovirus containing a large attachment glycoprotein is avirulent but immunoprotective in domestic turkeys. Bennett, R.S., LaRue, R., Shaw, D., Yu, Q., Nagaraja, K.V., Halvorson, D.A., Njenga, M.K. J. Virol. (2005) [Pubmed]
  8. Rescue of synthetic minireplicons establishes the absence of the NS1 and NS2 genes from avian pneumovirus. Randhawa, J.S., Marriott, A.C., Pringle, C.R., Easton, A.J. J. Virol. (1997) [Pubmed]
  9. Effect of ribavirin and glucocorticoid treatment in a mouse model of human metapneumovirus infection. Hamelin, M.E., Prince, G.A., Boivin, G. Antimicrob. Agents Chemother. (2006) [Pubmed]
  10. Recombinant human Metapneumovirus lacking the small hydrophobic SH and/or attachment G glycoprotein: deletion of G yields a promising vaccine candidate. Biacchesi, S., Skiadopoulos, M.H., Yang, L., Lamirande, E.W., Tran, K.C., Murphy, B.R., Collins, P.L., Buchholz, U.J. J. Virol. (2004) [Pubmed]
  11. Sequence and in vitro expression of the M2 gene of turkey rhinotracheitis pneumovirus. Yu, Q., Davis, P.J., Brown, T.D., Cavanagh, D. J. Gen. Virol. (1992) [Pubmed]
  12. Immunohistochemical detection of avian pneumovirus in formalin-fixed tissues. Jirjis, F.E., Noll, S.L., Halvorson, D.A., Nagaraja, K.V., Shaw, D.P. J. Vet. Diagn. Invest. (2001) [Pubmed]
  13. Evaluation of a Japanese quail fibrosarcoma cell line (QT-35) for use in the propagation and detection of metapneumovirus. Sabara, M.I., Larence, J.E. J. Virol. Methods (2002) [Pubmed]
  14. Plaque assay for avian metapneumovirus using a Japanese quail fibrosarcoma cell line (QT-35). Sabara, M.I., Larence, J.E. J. Virol. Methods (2003) [Pubmed]
  15. Complete sequence of the G glycoprotein gene of avian metapneumovirus subgroup C and identification of a divergent domain in the predicted protein. Govindarajan, D., Yunus, A.S., Samal, S.K. J. Gen. Virol. (2004) [Pubmed]
  16. Development of a reverse-genetics system for Avian pneumovirus demonstrates that the small hydrophobic (SH) and attachment (G) genes are not essential for virus viability. Naylor, C.J., Brown, P.A., Edworthy, N., Ling, R., Jones, R.C., Savage, C.E., Easton, A.J. J. Gen. Virol. (2004) [Pubmed]
  17. Detection of human metapneumovirus from children with acute otitis media. Suzuki, A., Watanabe, O., Okamoto, M., Endo, H., Yano, H., Suetake, M., Nishimura, H. Pediatr. Infect. Dis. J. (2005) [Pubmed]
  18. Deduced amino acid sequence of the small hydrophobic protein of US avian pneumovirus has greater identity with that of human metapneumovirus than those of non-US avian pneumoviruses. Yunus, A.S., Govindarajan, D., Huang, Z., Samal, S.K. Virus Res. (2003) [Pubmed]
  19. Two RT-PCR based assays to detect human metapneumovirus in nasopharyngeal aspirates. López-Huertas, M.R., Casas, I., Acosta-Herrera, B., García, M.L., Coiras, M.T., Pérez-Breña, P. J. Virol. Methods (2005) [Pubmed]
  20. Studies explore impact of new pathogens: investigators report on metapneumovirus, SARS. Stephenson, J. JAMA (2003) [Pubmed]
  21. Detection of severe human metapneumovirus infection by real-time polymerase chain reaction and histopathological assessment. Sumino, K.C., Agapov, E., Pierce, R.A., Trulock, E.P., Pfeifer, J.D., Ritter, J.H., Gaudreault-Keener, M., Storch, G.A., Holtzman, M.J. J. Infect. Dis. (2005) [Pubmed]
  22. Subgroup C avian metapneumovirus (MPV) and the recently isolated human MPV exhibit a common organization but have extensive sequence divergence in their putative SH and G genes. Toquin, D., de Boisseson, C., Beven, V., Senne, D.A., Eterradossi, N. J. Gen. Virol. (2003) [Pubmed]
  23. Detection and characterization of proteins encoded by the second ORF of the M2 gene of pneumoviruses. Ahmadian, G., Chambers, P., Easton, A.J. J. Gen. Virol. (1999) [Pubmed]
  24. Nucleotide and predicted amino acid sequence-based analysis of the avian metapneumovirus type C cell attachment glycoprotein gene: phylogenetic analysis and molecular epidemiology of U.S. pneumoviruses. Alvarez, R., Lwamba, H.M., Kapczynski, D.R., Njenga, M.K., Seal, B.S. J. Clin. Microbiol. (2003) [Pubmed]
  25. Human metapneumovirus infection in hematopoietic stem cell transplant recipients: high-resolution computed tomography findings. Franquet, T., Rodríguez, S., Martino, R., Salinas, T., Giménez, A., Hidalgo, A. Journal of computer assisted tomography. (2005) [Pubmed]
  26. Development of a nucleoprotein-based enzyme-linked immunosorbent assay using a synthetic peptide antigen for detection of avian metapneumovirus antibodies in Turkey sera. Alvarez, R., Njenga, M.K., Scott, M., Seal, B.S. Clin. Diagn. Lab. Immunol. (2004) [Pubmed]
  27. Sequence analysis of the large polymerase (L) protein of the US strain of avian metapneumovirus indicates a close resemblance to that of the human metapneumovirus. Govindarajan, D., Samal, S.K. Virus Res. (2004) [Pubmed]
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