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Gene Review

PAEP  -  progestagen-associated endometrial protein

Bos taurus

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Disease relevance of LGB

  • METHODS: Serum antibody levels against six cow's milk proteins, alpha-casein, alpha-lactalbumin (LA), beta-lactoglobulin A (LGA), beta-lactoglobulin B (LGB), bovine serum albumin (BSA), and whole milk powder (MP) were determined before and after (mean, 24 months) proctocolectomy in 15 patients with ulcerative colitis [1].

High impact information on LGB

  • The major milk proteins consist of the four caseins, alpha s1 (CASAS1), alpha s2 (CASAS2), beta (CASB), and kappa (CASK), as well as the two major whey proteins, alpha-lactalbumin (LALBA) and beta-lactoglobulin (LGB) [2].
  • In addition, a biallelic polymorphism in the beta-lactoglobulin gene (LGB) has been genetically positioned relative to the microsatellite markers [3].
  • With a combination of non-isotopic in situ hybridization and simultaneous fluorescent R-banding, this study presents the first map of the short arm of sheep Chromosome (Chr) 3 and of the homoeologous cattle and goat Chrs 11 with two DNA sequences: the beta lactoglobulin gene (LGB) and an immunoglobulin M heavy chain-like sequence (IGHML) [4].


  1. The effect of proctocolectomy on serum antibody levels against cow's milk proteins in patients with chronic ulcerative colitis, with special reference to liver changes. Aitola, P.T., Soppi, E.T., Halonen, P.J., Laine, S.T., Matikainen, M.J. Scand. J. Gastroenterol. (1994) [Pubmed]
  2. Genomic analysis of the major bovine milk protein genes. Threadgill, D.W., Womack, J.E. Nucleic Acids Res. (1990) [Pubmed]
  3. A genetic and physical map of bovine chromosome 11. Vaiman, D., Mercier, D., Eggen, A., Bahri-Darwich, I., Grohs, C., Cribiu, E.P., Dolf, G., Oustry, A., Guérin, G., Levéziel, H. Mamm. Genome (1994) [Pubmed]
  4. Mapping of the beta-lactoglobulin gene and of an immunoglobulin M heavy chain-like sequence to homoeologous cattle, sheep, and goat chromosomes. Hayes, H.C., Petit, E.J. Mamm. Genome (1993) [Pubmed]
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