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Gene Review

BLG  -  beta-lactoglobulin

Ovis aries

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Disease relevance of BLG

  • A BLG transgene displayed a similar tissue-specific pattern of DNAaseI hypersensitivity in mice [1].
  • Taken together, these results suggest that the absence of sufficient mammary-specific regulatory elements in the BLG promoter sequences and/or the juxtaposition of the BLG promoter with the HSA coding sequences leads to novel tissue- and cell-specific expression in ectopic tissues of transgenic mice [2].
  • Also included in A was a composite group of Pasteurella pneumotropica and P. gallinarum, together with unnamed groups referred to as 'BLG', 'Mair', 'Ross' and 'aer-2'. Area B contained species of Yersinia: Y. enterocolitica, Y. pseudotuberculosis, Y. pestis and a group 'ent-b' similar to Y. enterocolitica [3].
  • Sequence analyses of DD- and SSH-identified and cloned cDNAs indicated similarity of some to known mRNAs, including beta-lactoglobulin, alkaline phosphatase, type B and D endogenous sheep retroviruses, gp330/megalin, matrix Gla protein, and others [4].

High impact information on BLG


Biological context of BLG


Anatomical context of BLG


Associations of BLG with chemical compounds


Physical interactions of BLG


Enzymatic interactions of BLG


Other interactions of BLG


Analytical, diagnostic and therapeutic context of BLG


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  2. Ectopic expression of beta-lactoglobulin/human serum albumin fusion genes in transgenic mice: hormonal regulation and in situ localization. Barash, I., Faerman, A., Ratovitsky, T., Puzis, R., Nathan, M., Hurwitz, D.R., Shani, M. Transgenic Res. (1994) [Pubmed]
  3. A numerical taxonomic study of Actinobacillus, Pasteurella and Yersinia. Sneath, P.H., Stevens, M. J. Gen. Microbiol. (1985) [Pubmed]
  4. Discovery and characterization of endometrial epithelial messenger ribonucleic acids using the ovine uterine gland knockout model. Spencer, T.E., Stagg, A.G., Joyce, M.M., Jenster, G., Wood, C.G., Bazer, F.W., Wiley, A.A., Bartol, F.F. Endocrinology (1999) [Pubmed]
  5. Alteration of the quality of milk by expression of sheep beta-lactoglobulin in transgenic mice. Simons, J.P., McClenaghan, M., Clark, A.J. Nature (1987) [Pubmed]
  6. Regulation of the sheep beta-lactoglobulin gene by lactogenic hormones is mediated by a transcription factor that binds an interferon-gamma activation site-related element. Burdon, T.G., Maitland, K.A., Clark, A.J., Wallace, R., Watson, C.J. Mol. Endocrinol. (1994) [Pubmed]
  7. Interaction of DNA-binding proteins with a milk protein gene promoter in vitro: identification of a mammary gland-specific factor. Watson, C.J., Gordon, K.E., Robertson, M., Clark, A.J. Nucleic Acids Res. (1991) [Pubmed]
  8. Complete nucleotide sequence of the genomic ovine beta-lactoglobulin gene. Harris, S., Ali, S., Anderson, S., Archibald, A.L., Clark, A.J. Nucleic Acids Res. (1988) [Pubmed]
  9. Isolation and characterization of casein mRNAs from lactating ewe mammary glands. Gaye, P., Houdebine, L.M. Nucleic Acids Res. (1975) [Pubmed]
  10. Characterization of the gene encoding ovine beta-lactoglobulin. Similarity to the genes for retinol binding protein and other secretory proteins. Ali, S., Clark, A.J. J. Mol. Biol. (1988) [Pubmed]
  11. Ovine beta-lactoglobulin messenger RNA: nucleotide sequence and mRNA levels during functional differentiation of the mammary gland. Gaye, P., Hue-Delahaie, D., Mercier, J.C., Soulier, S., Vilotte, J.L., Furet, J.P. Biochimie (1986) [Pubmed]
  12. Developmental regulation of the sheep beta-lactoglobulin gene in the mammary gland of transgenic mice. Harris, S., McClenaghan, M., Simons, J.P., Ali, S., Clark, A.J. Dev. Genet. (1991) [Pubmed]
  13. Colostrum protein digestion in newborn lambs. Yvon, M., Levieux, D., Valluy, M.C., Pélissier, J.P., Mirand, P.P. J. Nutr. (1993) [Pubmed]
  14. Matrix attachment region regulates basal beta-lactoglobulin transgene expression. Whitelaw, C.B., Grolli, S., Accornero, P., Donofrio, G., Farini, E., Webster, J. Gene (2000) [Pubmed]
  15. Characterization of turkey pancreatic lipase. Sayari, A., Mejdoub, H., Gargouri, Y. Biochimie (2000) [Pubmed]
  16. Hormone-dependent expression of the ovine beta-lactoglobulin gene. Osborne, R., Howell, M., Clark, A.J., Nicholas, K.R. J. Dairy Res. (1995) [Pubmed]
  17. Isolation and identification of some major water-soluble peptides in Feta cheese. Michaelidou, A., Alichanidis, E., Urlaub, H., Polychroniadou, A., Zerfiridis, G.K. J. Dairy Sci. (1998) [Pubmed]
  18. Proteolytic degradation of ewe milk proteins during fermentation of yoghurts and storage. El-Zahar, K., Chobert, J.M., Sitohy, M., Dalgalarrondo, M., Haertlé, T. Die Nahrung. (2003) [Pubmed]
  19. The proximal milk protein binding factor binding site is required for the prolactin responsiveness of the sheep beta-lactoglobulin promoter in Chinese hamster ovary cells. Demmer, J., Burdon, T.G., Djiane, J., Watson, C.J., Clark, A.J. Mol. Cell. Endocrinol. (1995) [Pubmed]
  20. Milk protein synthesis, gene expression, and hormonal responsiveness in primary cultures of mammary cells from lactating sheep. Wheeler, T.T., Callaghan, M.R., Davis, S.R., Prosser, C.G., Wilkins, R.J. Exp. Cell Res. (1995) [Pubmed]
  21. Construction and identification of recombinant plasmids carrying cDNAs coding for ovine alpha S1-, alpha S2-, beta-, kappa-casein and beta-lactoglobulin. Nucleotide sequence of alpha S1-casein cDNA. Mercier, J.C., Gaye, P., Soulier, S., Hue-Delahaie, D., Vilotte, J.L. Biochimie (1985) [Pubmed]
  22. On-line capillary isoelectric focusing-mass spectrometry for quantitative analysis of peptides and proteins. Kuroda, Y., Yukinaga, H., Kitano, M., Noguchi, T., Nemati, M., Shibukawa, A., Nakagawa, T., Matsuzaki, K. Journal of pharmaceutical and biomedical analysis. (2005) [Pubmed]
  23. Synthesis and secretion of human serum albumin by mammary gland explants of virgin and lactating transgenic mice. Barash, I., Faerman, A., Baruch, A., Nathan, M., Hurwitz, D.R., Shani, M. Transgenic Res. (1993) [Pubmed]
  24. Construction of La-tPA vector and expression in the mammary gland of transgenic mice. Lu, Y., Deng, J., Cheng, X., Zhou, J., Huang, P. Chin. J. Biotechnol. (1999) [Pubmed]
  25. Expression and secretion of recombinant ovine beta-lactoglobulin in Saccharomyces cerevisiae and Kluyveromyces lactis. Rocha, T.L., Paterson, G., Crimmins, K., Boyd, A., Sawyer, L., Fothergill-Gilmore, L.A. Biochem. J. (1996) [Pubmed]
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