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Gene Review

COX4I1  -  cytochrome c oxidase subunit IV isoform 1

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High impact information on COX4

  • Zn(II) binding in Cox4 is, therefore, important for the stability of the complex [1].
  • Substitutions at the Cys ligand positions result in non-functional Cox4 proteins that fail to lead to cytochrome oxidase assembly [1].
  • Cox4 is the only cofactor-containing subunit that is not directly part of the catalytic core of the enzyme located in the mitochondrial inner membrane [1].
  • The structure and expression of the gene (COX4) encoding bovine cytochrome c oxidase subunit IV (COX IV) was studied in order to identify conserved DNA sequence elements involved in the control of mammalian nuclear respiratory genes [2].
  • Comparative analysis of bovine, rat and mouse COX4 promoters identified multiple binding sites for the regulatory proteins Sp1 and GABP (NRF-2) [2].

Biological context of COX4

  • The functional bovine COX4 gene consists of five exons and four introns and is similar in organization to rat and mouse COX4 [2].


  1. The characterization and role of zinc binding in yeast cox4. Coyne, H.J., Ciofi-Baffoni, S., Banci, L., Bertini, I., Zhang, L., George, G.N., Winge, D.R. J. Biol. Chem. (2007) [Pubmed]
  2. Isolation and characterization of the functional gene encoding bovine cytochrome c oxidase subunit IV. Bachman, N.J. Gene (1995) [Pubmed]
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