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Gene Review

COX4I1  -  cytochrome c oxidase subunit IV isoform 1

Homo sapiens

Synonyms: COX IV-1, COX4, COX4-1, COXIV, Cytochrome c oxidase polypeptide IV, ...
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High impact information on COX4I1

  • We have compared the DNA sequences of nine mammalian genes for cytochrome c oxidase subunit IV (COX4 genes)--four expressed genes (human, bovine, rat, and mouse) and five pseudogenes (human, chimpanzee, orangutan, squirrel monkey, and bovine)--and constructed the sequence of the ancestral mammalian COX4 gene [1].
  • In addition, reduced RNA expression of two other genes at 8E1 encoding COX4I1 and RPL13 could be explained by a decrease in chromosomal copy number on chromosome 8 [2].
  • Here we examined COX IV evolution in the two groups of anthropoid primates, the catarrhines (hominoids, cercopithecoids) and platyrrhines (ceboids), as well as one prosimian primate (lorisiform), by sequencing PCR-amplified portions of functional COX4 genes from genomic DNAs [3].
  • Cultured K-562 cells were incubated with varying concentrations of ADR.HCl (0.2 microM to 5 microM) in the presence and absence of hemin (30 microM) and assessed for DNA degradation, as well as for expression of mitochondrial COXII and nuclear COXIV genes by RNA Northern blot hybridization analysis [4].
  • By screening Chinese hamster x human hybrid panels with the human COX4 cDNA, we have mapped COX4 genes to two human chromosomes, 14 and 16 [5].

Biological context of COX4I1


Anatomical context of COX4I1


Regulatory relationships of COX4I1

  • Transcript levels of mitochondrial-encoded ATP synthase 6/8 were similarly upregulated in these tissues whereas transcript levels of the nuclear encoded subunits Cox4 and ATP synthase alpha did not change during hibernation [10].

Other interactions of COX4I1

  • Quantitative real-time PCR and Western blotting showed the expression of mitochondrial-encoded COX subunit III (COXIII) dropped significantly during the chronic seizure activity; the corresponding expression of COX subunit IV (COXIV) displayed no significant change [11].

Analytical, diagnostic and therapeutic context of COX4I1


  1. Rapid evolution of the human gene for cytochrome c oxidase subunit IV. Lomax, M.I., Hewett-Emmett, D., Yang, T.L., Grossman, L.I. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  2. Expression microarray analysis and oligo array comparative genomic hybridization of acquired gemcitabine resistance in mouse colon reveals selection for chromosomal aberrations. van de Wiel, M.A., Costa, J.L., Smid, K., Oudejans, C.B., Bergman, A.M., Meijer, G.A., Peters, G.J., Ylstra, B. Cancer Res. (2005) [Pubmed]
  3. Molecular evolution of cytochrome c oxidase subunit IV: evidence for positive selection in simian primates. Wu, W., Goodman, M., Lomax, M.I., Grossman, L.I. J. Mol. Evol. (1997) [Pubmed]
  4. Effects of hemin on apoptosis, suppression of cytochrome c oxidase gene expression, and bone-marrow toxicity induced by doxorubicin (adriamycin). Papadopoulou, L.C., Tsiftsoglou, A.S. Biochem. Pharmacol. (1996) [Pubmed]
  5. Novel use of a chimpanzee pseudogene for chromosomal mapping of human cytochrome c oxidase subunit IV. Lomax, M.I., Welch, M.D., Darras, B.T., Francke, U., Grossman, L.I. Gene (1990) [Pubmed]
  6. The 5' region of the COX4 gene contains a novel overlapping gene, NOC4. Bachman, N.J., Wu, W., Schmidt, T.R., Grossman, L.I., Lomax, M.I. Mamm. Genome (1999) [Pubmed]
  7. The translation state of differentially expressed mRNAs in the hibernating 13-lined ground squirrel (Spermophilus tridecemlineatus). Hittel, D., Storey, K.B. Arch. Biochem. Biophys. (2002) [Pubmed]
  8. Cloning and characterization of the mouse cytochrome c oxidase subunit IV gene. Carter, R.S., Avadhani, N.G. Arch. Biochem. Biophys. (1991) [Pubmed]
  9. Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex. Macdonald, P., Palmer, J., Kirby, J.A., Jones, D.E. Clin. Exp. Immunol. (2004) [Pubmed]
  10. Differential expression of mitochondria-encoded genes in a hibernating mammal. Hittel, D.S., Storey, K.B. J. Exp. Biol. (2002) [Pubmed]
  11. Mitochondrial dysfunction and ultrastructural damage in the hippocampus of pilocarpine-induced epileptic rat. Gao, J., Chi, Z.F., Liu, X.W., Shan, P.Y., Wang, R. Neurosci. Lett. (2007) [Pubmed]
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