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ECE2  -  endothelin converting enzyme 2

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High impact information on ECE2

  • These findings suggest that ECE-2 acts as an intracellular enzyme responsible for the conversion of endogenously synthesized big ET-1 at the trans-Golgi network, where the vesicular fluid is acidified [1].
  • Chinese hamster ovary (CHO) cells, which lack detectable levels of endogenous ECE activity, secrete mature ET-1 into the medium when doubly transfected with ECE-2 and prepro-ET-1 cDNAs [1].
  • ECE-2 and cathpesins B, D, and L were detected only in the cytosol of both the retina and ON [2].

Analytical, diagnostic and therapeutic context of ECE2


  1. Endothelin-converting enzyme-2 is a membrane-bound, phosphoramidon-sensitive metalloprotease with acidic pH optimum. Emoto, N., Yanagisawa, M. J. Biol. Chem. (1995) [Pubmed]
  2. Localization of endothelin-converting enzyme in bovine optic nerve and retina. Dibas, A., Prasanna, G., Yorio, T. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2005) [Pubmed]
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