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Gene Review

ECE2  -  endothelin converting enzyme 2

Homo sapiens

Synonyms: ECE-2, Endothelin-converting enzyme 2, KIAA0604, MGC2408, UNQ403/PRO740
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High impact information on ECE2

  • Optimal ECE activity was measured at pH 6.0, a value intermediate between that reported for ECE-1 (pH 6.8) and ECE-2 (pH 5.5), indicating expression of both enzymes [1].
  • Confocal microscopy revealed a punctate pattern of ECE-2-like immunoreactive staining in the cell cytosol, suggesting localization to secretory vesicles with a possible role in processing big ET-1 while in transit to the cell surface via the constitutive secretory pathway [1].
  • Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells [1].
  • 4 (IC50 1.5 nmol/L), consistent with ECE-2 activity [1].
  • Of the other genes, PPET-2 and ET(B) were expressed in all tissue specimens and no differences were observed between tumor subtypes or tumor-affected and normal tissue specimens, whereas PPET-3 and ECE-2 were present in all tissue specimens but were barely detectable [2].

Biological context of ECE2


Anatomical context of ECE2


Regulatory relationships of ECE2

  • These results suggest ECE-1b and ECE-2 may be widely expressed in normal tissue from humans and inhibition of ECE-1 isoforms and ECE-2 expressed by cells such as macrophages in pathophysiological tissue may be an additional therapeutic target in cardiovascular disease [4].

Other interactions of ECE2

  • A second enzyme, ECE-2, also exists as four isoforms and differs from ECE-1 in requiring an acidic pH for optimal activity [5].

Analytical, diagnostic and therapeutic context of ECE2


  1. Evidence for intracellular endothelin-converting enzyme-2 expression in cultured human vascular endothelial cells. Russell, F.D., Davenport, A.P. Circ. Res. (1999) [Pubmed]
  2. Endothelin axis expression is markedly different in the two main subtypes of renal cell carcinoma. Douglas, M.L., Richardson, M.M., Nicol, D.L. Cancer (2004) [Pubmed]
  3. Human endothelin converting enzyme-2 (ECE2): characterization of mRNA species and chromosomal localization. Lorenzo, M.N., Khan, R.Y., Wang, Y., Tai, S.C., Chan, G.C., Cheung, A.H., Marsden, P.A. Biochim. Biophys. Acta (2001) [Pubmed]
  4. Cellular expression of isoforms of endothelin-converting enzyme-1 (ECE-1c, ECE-1b and ECE-1a) and endothelin-converting enzyme-2. Davenport, A.P., Kuc, R.E. J. Cardiovasc. Pharmacol. (2000) [Pubmed]
  5. Endothelin. Davenport, A.P., Maguire, J.J. Handbook of experimental pharmacology. (2006) [Pubmed]
  6. Characterization of endothelin-converting enzyme activities in ARPE-19 cells, a human retinal pigmented epithelial cell line. Dibas, A., Prasanna, G., Yorio, T. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics. (2005) [Pubmed]
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