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Gene Review

LDHA  -  lactate dehydrogenase A

Bos taurus

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Disease relevance of LDHA


High impact information on LDHA

  • LDH-A and LDH-B were detected in bovine oocytes and in all stages of IVF and NT embryos examined up to the blastocyst stage [2].
  • In this paper, we describe the accumulation of lactic acid in the culture medium of growing, engineered yeast cells expressing a mammalian lactate dehydrogenase gene (LDH-A) [3].


  1. Primary structure of bovine lactate dehydrogenase-A isozyme and its synthesis in Escherichia coli. Ishiguro, N., Osame, S., Kagiya, R., Ichijo, S., Shinagawa, M. Gene (1990) [Pubmed]
  2. Genetic reprogramming of lactate dehydrogenase, citrate synthase, and phosphofructokinase mRNA in bovine nuclear transfer embryos produced using bovine fibroblast cell nuclei. Winger, Q.A., Hill, J.R., Shin, T., Watson, A.J., Kraemer, D.C., Westhusin, M.E. Mol. Reprod. Dev. (2000) [Pubmed]
  3. Development of metabolically engineered Saccharomyces cerevisiae cells for the production of lactic acid. Porro, D., Brambilla, L., Ranzi, B.M., Martegani, E., Alberghina, L. Biotechnol. Prog. (1995) [Pubmed]
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