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Gene Review

NCF1  -  neutrophil cytosolic factor 1

Bos taurus

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High impact information on NCF1

  • Comparison of the bovine sequences with those of the human and murine homologs showed that they were highly conserved, but also revealed important information regarding key structural features of p47-phox and p67-phox, including location of putative phosphorylation sites [1].
  • This study greatly contributes to our understanding of the potential structural/functional regions of p47-phox and p67-phox as well as providing information that can be used to study the role of neutrophils in bovine inflammatory diseases [1].
  • The NAD(P)H oxidase subcomponents p47phox and p22phox were assessed by immunofluorescent microscopy and Western blot [2].
  • We also studied endothelial cells lacking the p47phox subunit of the NAD(P)H oxidase [3].
  • Transfection of these cells with p47phox restored XO protein levels [3].

Anatomical context of NCF1

  • Following incubation of a cytosolic extract from nonactivated bovine neutrophil with protein A-Sepharose bound to anti-p67phox antibodies, the recovered immunoprecipitate contained the S100 protein, p47phox and p67phox [4].

Other interactions of NCF1

  • When neutrophils are exposed to a variety of particulate or soluble stimuli, the oxidase becomes activated, due to the assembly on the membrane-bound flavocytochrome b of three cytosolic factors, p47phox, p67phox and Rac 2 (or Rac 1) [5].
  • Furthermore, stretch caused an increase in EGFR phosphorylation and cytosolic to membrane translocation of the p47phox NAD(P)H oxidase subunit [6].


  1. Cloning and expression of bovine p47-phox and p67-phox: comparison with the human and murine homologs. Bunger, P.L., Swain, S.D., Clements, M.K., Siemsen, D.W., Davis, A.R., Gauss, K.A., Quinn, M.T. J. Leukoc. Biol. (2000) [Pubmed]
  2. NAD(P)H oxidase mediates the endothelial barrier dysfunction induced by TNF-alpha. Gertzberg, N., Neumann, P., Rizzo, V., Johnson, A. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
  3. Role of xanthine oxidoreductase and NAD(P)H oxidase in endothelial superoxide production in response to oscillatory shear stress. McNally, J.S., Davis, M.E., Giddens, D.P., Saha, A., Hwang, J., Dikalov, S., Jo, H., Harrison, D.G. Am. J. Physiol. Heart Circ. Physiol. (2003) [Pubmed]
  4. The S100A8/A9 protein as a partner for the cytosolic factors of NADPH oxidase activation in neutrophils. Doussiere, J., Bouzidi, F., Vignais, P.V. Eur. J. Biochem. (2002) [Pubmed]
  5. Phenylarsine oxide as an inhibitor of the activation of the neutrophil NADPH oxidase--identification of the beta subunit of the flavocytochrome b component of the NADPH oxidase as a target site for phenylarsine oxide by photoaffinity labeling and photoinactivation. Doussiere, J., Poinas, A., Blais, C., Vignais, P.V. Eur. J. Biochem. (1998) [Pubmed]
  6. Stretch enhances contraction of bovine coronary arteries via an NAD(P)H oxidase-mediated activation of the extracellular signal-regulated kinase mitogen-activated protein kinase cascade. Oeckler, R.A., Kaminski, P.M., Wolin, M.S. Circ. Res. (2003) [Pubmed]
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