Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

CYBA - cytochrome b-245, alpha polypeptide

Bos taurus

Ying, C.J. et al., Silacci, P. et al., Sankarapandi, S. et al., Gertzberg, N. et al.

Ying, Sun, Zhang, Zhang, Mao, Zuo, Yao, Silacci, Desgeorges, Mazzolai, Chambaz, Hayoz,

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High impact information on CYBA

The NAD(P)H oxidase subcomponents p47phox and p22phox were assessed by immunofluorescent microscopy and Western blot [1].
Western blots of microglia lysates demonstrated that both large (gp91-phox) and small (p22-phox) NADPH oxidase subunits are expressed in both unstimulated and stimulated microglia [2].
RESULTS: Tea polyphenols of 0.4 microg/mL and 4.0 microg/mL (from either green tea or black tea) down-regulated NADPH oxidase p22phox and p67phox expressions in a dose-negative manner (P < 0.05), and up-regulated the expressions of catalase (P < 0.05) [3].
P22phox mRNA level increased in cells exposed to both unidirectional and oscillatory shear stress, suggesting that p22phox gene expression upregulation contributes to flow-induced increase in superoxide anion production in endothelial cells [4].

References

NAD(P)H oxidase mediates the endothelial barrier dysfunction induced by TNF-alpha. Gertzberg, N., Neumann, P., Rizzo, V., Johnson, A. Am. J. Physiol. Lung Cell Mol. Physiol. (2004) [Pubmed]
Measurement and characterization of superoxide generation in microglial cells: evidence for an NADPH oxidase-dependent pathway. Sankarapandi, S., Zweier, J.L., Mukherjee, G., Quinn, M.T., Huso, D.L. Arch. Biochem. Biophys. (1998) [Pubmed]
ROS-related enzyme expressions in endothelial cells regulated by tea polyphenols. Ying, C.J., Sun, X.F., Zhang, S.L., Zhang, X.P., Mao, L.M., Zuo, X.Z., Yao, P. Biomed. Environ. Sci. (2004) [Pubmed]
Flow pulsatility is a critical determinant of oxidative stress in endothelial cells. Silacci, P., Desgeorges, A., Mazzolai, L., Chambaz, C., Hayoz, D. Hypertension (2001) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CYBA	Canis lupus familiaris
cyba	Danio rerio
CYBA	Homo sapiens
LOC696748	Macaca mulatta
Cyba	Mus musculus
CYBA	Pan troglodytes
Cyba	Rattus norvegicus
cyba	Xenopus (Silurana) tropicalis

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