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Gene Review:

EPB41 - erythrocyte membrane protein band 4.1

Bos taurus

Aster, J.C. et al., Holt, G.D. et al., Baines, A.J. et al., Leto, T.L. et al., Baines, A.J. et al., et al.

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High impact information on EPB41

Synapsin or protein 4.1 in chromaffin cells [1].
Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1 [2].
Analogous to RBC protein 4.1, these proteins may function in the lens by promoting association of spectrin with actin and by playing a role in the coupling of lens cytoskeleton to plasma membrane [3].
To further study their relationship to protein 4.1, these proteins were immunoprecipitated from detergent extracts of crude lens membranes with purified polyclonal and monoclonal anti-4.1 antibodies and resolved by SDS PAGE [3].
In addition, we have determined that Band 4.1, a protein which serves as a bridge joining the cytoskeleton to the inner surface of the plasma membrane in erythrocytes, also contains O-GlcNAc moieties [4].

Anatomical context of EPB41

However, despite its recent characterization as a spectrin-binding protein immunologically related to erythrocyte protein 4.1, other interactions of synapsin I with structural proteins remain unknown [5].
These data suggest that, in endothelial cells, protein 4.1 is a cortical membrane protein which may function to link actin filaments to other skeletal proteins such as spectrin [6].

Associations of EPB41 with chemical compounds

Erythrocytes contain cytoplasmic glycoproteins. O-linked GlcNAc on Band 4.1 [4].

References

Synapsin or protein 4.1 in chromaffin cells. Burgoyne, R.D., Baines, A.J. Nature (1987) [Pubmed]
Synapsin I is a spectrin-binding protein immunologically related to erythrocyte protein 4.1. Baines, A.J., Bennett, V. Nature (1985) [Pubmed]
The 4.1-like proteins of the bovine lens: spectrin-binding proteins closely related in structure to red blood cell protein 4.1. Aster, J.C., Brewer, G.J., Maisel, H. J. Cell Biol. (1986) [Pubmed]
Erythrocytes contain cytoplasmic glycoproteins. O-linked GlcNAc on Band 4.1. Holt, G.D., Haltiwanger, R.S., Torres, C.R., Hart, G.W. J. Biol. Chem. (1987) [Pubmed]
Synapsin I is a microtubule-bundling protein. Baines, A.J., Bennett, V. Nature (1986) [Pubmed]
Mechanisms of cytoskeletal regulation: modulation of aortic endothelial cell protein band 4.1 by the extracellular matrix. Leto, T.L., Pratt, B.M., Madri, J.A. J. Cell. Physiol. (1986) [Pubmed]

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EPB41	Canis lupus familiaris
EPB41	Gallus gallus
EPB41	Homo sapiens
Epb4.1	Mus musculus
EPB41	Pan troglodytes
Epb4.1	Rattus norvegicus
epb41	Xenopus (Silurana) tropicalis

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