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GNA11  -  guanine nucleotide binding protein (G...

Bos taurus

 
 
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Disease relevance of GNA11

  • We suggest that GL1 alpha and GL2 alpha are new members of a subfamily of pertussis toxin-insensitive G-proteins [1].
 

High impact information on GNA11

  • Phospholipase C-beta stimulated the GTPase activity of GL1, GL2, and Gq in the presence of m1 receptor and carbamylcholine but did not stimulate the GTPase activity of GO [2].
  • The chimeric receptor showed no electrophysiological responses to ACh when expressed alone in oocytes, but became responsive to ACh when co-expressed with GL2 alpha [3].
 

Anatomical context of GNA11

  • When expressed in Xenopus oocytes together with metabotropic glutamate receptors, GL2 alpha activates endogenous phospholipase C (PLCx) in response to glutamate stimulation, whereas GL1 alpha inhibits the activation of PLCx [4].
 

Associations of GNA11 with chemical compounds

  • GL1, GL2, and Gq activated phospholipase C-beta purified from bovine brain in the presence of aluminum fluoride to the same extent [2].
  • The expression of GL2 alpha, GL1 alpha or Gs alpha caused potentiation, suppression and no change, respectively, on the fluoride- (or GTP gamma S-) evoked reactions.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
  • Further analyses indicated that GL2 alpha amplified the activity of endogenous muscarinic ACh receptors that are expressed at an otherwise undetectable level, and thus made their detection possible [3].
 

Other interactions of GNA11

  • Both GL1 alpha and GL2 alpha lack a consensus site for ADP-ribosylation by pertussis toxin [1].

References

  1. Identification of two novel GTP-binding protein alpha-subunits that lack apparent ADP-ribosylation sites for pertussis toxin. Nakamura, F., Ogata, K., Shiozaki, K., Kameyama, K., Ohara, K., Haga, T., Nukada, T. J. Biol. Chem. (1991) [Pubmed]
  2. Characterization of Gq family G proteins GL1 alpha (G14 alpha), GL2 alpha (G11 alpha), and Gq alpha expressed in the baculovirus-insect cell system. Nakamura, F., Kato, M., Kameyama, K., Nukada, T., Haga, T., Kato, H., Takenawa, T., Kikkawa, U. J. Biol. Chem. (1995) [Pubmed]
  3. The G alpha protein GL2 alpha improves the ability to detect the subthreshold expressions of receptors linked to phospholipase C in Xenopus oocytes. Yamashita, S., Minakami, R., Sugiyama, H. Jpn. J. Physiol. (1997) [Pubmed]
  4. Importance of N-terminal regions of G protein alpha subunits for the activation of phospholipase C in Xenopus oocytes. Nakamura, K., Nukada, T., Imai, K., Sugiyama, H. J. Biochem. (1996) [Pubmed]
  5. G protein-mediated inhibition of phosphoinositide metabolism evoked by metabotropic glutamate receptors in frog oocytes. Nakamura, K., Nukada, T., Haga, T., Sugiyama, H. J. Physiol. (Lond.) (1994) [Pubmed]
 
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