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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

egl-30  -  Protein EGL-30

Caenorhabditis elegans

 
 
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High impact information on egl-30

  • Animals defective in both sag-1 and eat-16 are inviable, but reducing function in egl-30 restores viability, indicating that the lethality of the eat-16; sag-1 double mutant is due to excessive G(q)alpha activity [1].
  • We sought other components of the Goalpha-G(q)alpha signaling network by screening for aldicarb-resistant mutants with phenotypes similar to egl-30 (G(q)alpha) mutants [2].
  • We find that C. elegans egl-30 encodes a heterotrimeric G protein a subunit more than 80% identical to mammalian Gqalpha family proteins, and which can function as a Gqalpha subunit in COS-7 cells [3].
  • Two egl-30 alleles specify premature termination of Gqalpha and are essentially lethal in homozygotes [3].
  • We have identified new egl-30 alleles in a selection for genes involved in the C. elegans acetylcholine response [3].
 

Biological context of egl-30

 

Other interactions of egl-30

  • The effects of slo-1 and egl-30 on VA sensitivity can be explained by their actions upstream or parallel to syntaxin to increase the level of excitatory neurotransmitter release [6].

References

  1. Antagonism between G(o)alpha and G(q)alpha in Caenorhabditis elegans: the RGS protein EAT-16 is necessary for G(o)alpha signaling and regulates G(q)alpha activity. Hajdu-Cronin, Y.M., Chen, W.J., Patikoglou, G., Koelle, M.R., Sternberg, P.W. Genes Dev. (1999) [Pubmed]
  2. RIC-8 (Synembryn): a novel conserved protein that is required for G(q)alpha signaling in the C. elegans nervous system. Miller, K.G., Emerson, M.D., McManus, J.R., Rand, J.B. Neuron (2000) [Pubmed]
  3. Mutations in a C. elegans Gqalpha gene disrupt movement, egg laying, and viability. Brundage, L., Avery, L., Katz, A., Kim, U.J., Mendel, J.E., Sternberg, P.W., Simon, M.I. Neuron (1996) [Pubmed]
  4. Goalpha and diacylglycerol kinase negatively regulate the Gqalpha pathway in C. elegans. Miller, K.G., Emerson, M.D., Rand, J.B. Neuron (1999) [Pubmed]
  5. Caenorhabditis elegans Galphaq regulates egg-laying behavior via a PLCbeta-independent and serotonin-dependent signaling pathway and likely functions both in the nervous system and in muscle. Bastiani, C.A., Gharib, S., Simon, M.I., Sternberg, P.W. Genetics (2003) [Pubmed]
  6. Resistance to volatile anesthetics by mutations enhancing excitatory neurotransmitter release in Caenorhabditis elegans. Hawasli, A.H., Saifee, O., Liu, C., Nonet, M.L., Crowder, C.M. Genetics (2004) [Pubmed]
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