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Gene Review

GNA11  -  guanine nucleotide binding protein (G...

Homo sapiens

Synonyms: FBH, FBH2, FHH2, G alpha-11, G-protein subunit alpha-11, ...
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Disease relevance of GNA11

  • Electrophoretic analysis of the proteins bound to poly(3-hydroxybutyric acid), PHB-, granules in Methylobacterium extorquens, M. rhodesianum as well as the PHB-leaky mutants Mu 1 and Mu 11, which were isolated from the latter, resulted in two dominant low-molecular weight proteins, which were referred to as GA11 and GA20 [1].

High impact information on GNA11


Biological context of GNA11


Anatomical context of GNA11


Associations of GNA11 with chemical compounds

  • RT-PCR performed with gene-specific primers demonstrated G alpha q mRNA, but not G alpha 11 mRNA, in normal human and mouse platelets and in thromboxane-sensitive and thromboxane-insensitive dog platelets [7].
  • Cells that were prelabeled with the [3H]inositol and transfected with G alpha q and G alpha 11 cDNA showed marked increases in formation of [3H]inositol phosphates after stimulation with aluminum fluoride [8].
  • All of these results are consistent with the conclusion that G alpha q and G alpha 11 cDNA encode proteins that in the presence of GTP gamma S specifically activate PI-PLC [8].
  • Moreover, the catalytic activities of the recombinant enzyme were indistinguishable from those of native turkey erythrocyte PLC-beta in assays carried out in the presence of cholate and Ca2+, or in assays of activity after reconstitution with G alpha 11 or G-protein beta gamma-subunits [11].

Regulatory relationships of GNA11


Other interactions of GNA11


  1. Analysis of the PHA granule-associated proteins GA20 and GA11 in Methylobacterium extorquens and Methylobacterium rhodesianum. Föllner, C.G., Madkour, M., Mayer, F., Babel, W., Steinbüchel, A. J. Basic Microbiol. (1997) [Pubmed]
  2. G protein-coupled signal transduction pathways for interleukin-8. Wu, D., LaRosa, G.J., Simon, M.I. Science (1993) [Pubmed]
  3. Interaction between G proteins and tyrosine kinases upon T cell receptor.CD3-mediated signaling. Stanners, J., Kabouridis, P.S., McGuire, K.L., Tsoukas, C.D. J. Biol. Chem. (1995) [Pubmed]
  4. Selective coupling of beta 2-adrenergic receptor to hematopoietic-specific G proteins. Wu, D., Kuang, Y., Wu, Y., Jiang, H. J. Biol. Chem. (1995) [Pubmed]
  5. Activation of phospholipase C by alpha 1-adrenergic receptors is mediated by the alpha subunits of Gq family. Wu, D., Katz, A., Lee, C.H., Simon, M.I. J. Biol. Chem. (1992) [Pubmed]
  6. Reduced expression of GNA11 and silencing of MCT1 in human breast cancers. Asada, K., Miyamoto, K., Fukutomi, T., Tsuda, H., Yagi, Y., Wakazono, K., Oishi, S., Fukui, H., Sugimura, T., Ushijima, T. Oncology (2003) [Pubmed]
  7. Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences. Johnson, G.J., Leis, L.A., Dunlop, P.C. Biochem. J. (1996) [Pubmed]
  8. Activation of phospholipase C by the alpha subunits of the Gq and G11 proteins in transfected Cos-7 cells. Wu, D.Q., Lee, C.H., Rhee, S.G., Simon, M.I. J. Biol. Chem. (1992) [Pubmed]
  9. Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy. Europe-Finner, G.N., Phaneuf, S., Watson, S.P., López Bernal, A. Endocrinology (1993) [Pubmed]
  10. Differential G-protein expression during B- and T-cell development. Grant, K.R., Harnett, W., Milligan, G., Harnett, M.M. Immunology (1997) [Pubmed]
  11. Molecular cloning, expression and regulatory activity of G alpha 11- and beta gamma-subunit-stimulated phospholipase C-beta from avian erythrocytes. Waldo, G.L., Paterson, A., Boyer, J.L., Nicholas, R.A., Harden, T.K. Biochem. J. (1996) [Pubmed]
  12. Concentration of enzyme-dependent activation of PLC-beta 1 and PLC-beta 2 by G alpha 11 and beta gamma-subunits. Paterson, A., Boyer, J.L., Watts, V.J., Morris, A.J., Price, E.M., Harden, T.K. Cell. Signal. (1995) [Pubmed]
  13. Oxytocin stimulates myometrial guanosine triphosphatase and phospholipase-C activities via coupling to G alpha q/11. Ku, C.Y., Qian, A., Wen, Y., Anwer, K., Sanborn, B.M. Endocrinology (1995) [Pubmed]
  14. Screening of candidate oncogenes in human thyrotroph tumors: absence of activating mutations of the G alpha q, G alpha 11, G alpha s, or thyrotropin-releasing hormone receptor genes. Dong, Q., Brucker-Davis, F., Weintraub, B.D., Smallridge, R.C., Carr, F.E., Battey, J., Spiegel, A.M., Shenker, A. J. Clin. Endocrinol. Metab. (1996) [Pubmed]
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