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Gene Review:

KCNJ2 - potassium inwardly-rectifying channel,...

Bos taurus

Yang, D. et al., Forsyth, S.E. et al.

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High impact information on KCNJ2

CONCLUSIONS: Corneal endothelial cells express IRK1 (Kir2.1) inwardly rectifying K(+) channels [1].
RESULTS: A full-length (1284 bp) coding sequence that shares 99.7% nucleotide sequence and 100% amino acid sequence identity to bovine lens IRK1 (Kir2.1) was cloned [1].
Consistent with the properties of IRK1 channels, BCIRK1 is likely involved in regulating membrane potential and possibly other cellular functions in corneal endothelial cells [1].
Expression in Xenopus oocytes showed that BIK is a K+-specific strong inward rectifier channel that is sensitive to extracellular Ba2+, Cs+, and a variety of anti-arrhythmic agents [2].

Analytical, diagnostic and therapeutic context of KCNJ2

METHODS: An RT-PCR strategy was used to clone an IRK1 channel sequence from BCE mRNA [1].
Sequence analysis reveals that BIK is a member of the Kir2.1 family of inward rectifier K+ channels [2].

References

Molecular cloning and expression of an inwardly rectifying K(+) channel from bovine corneal endothelial cells. Yang, D., Sun, F., Thomas, L.L., Offord, J., MacCallum, D.K., Dawson, D.C., Hughes, B.A., Ernst, S.A. Invest. Ophthalmol. Vis. Sci. (2000) [Pubmed]
Molecular cloning and expression of a bovine endothelial inward rectifier potassium channel. Forsyth, S.E., Hoger, A., Hoger, J.H. FEBS Lett. (1997) [Pubmed]

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AgaP_AGAP001280	Anopheles gambiae str. PEST
irk-1	Caenorhabditis elegans
KCNJ2	Canis lupus familiaris
kcnj2a	Danio rerio
Irk1	Drosophila melanogaster
KCNJ2	Gallus gallus
KCNJ2	Homo sapiens
KCNJ2	Macaca mulatta
Kcnj2	Mus musculus
KCNJ2	Pan troglodytes
Kcnj2	Rattus norvegicus
kcnj2	Xenopus (Silurana) tropicalis

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