Gene Review:
Kcnj2 - potassium inwardly-rectifying channel,...
Mus musculus
Synonyms:
IRK-1, IRK1, Inward rectifier K(+) channel Kir2.1, Inward rectifier potassium channel 2, Irk1, ...
- The consequences of disrupting cardiac inwardly rectifying K(+) current (I(K1)) as revealed by the targeted deletion of the murine Kir2.1 and Kir2.2 genes. Zaritsky, J.J., Redell, J.B., Tempel, B.L., Schwarz, T.L. J. Physiol. (Lond.) (2001)
- The systemic inflammatory response is involved in the regulation of K(+) channel expression in brain via TNF-alpha-dependent and -independent pathways. Vicente, R., Coma, M., Busquets, S., Moore-Carrasco, R., López-Soriano, F.J., Argilés, J.M., Felipe, A. FEBS Lett. (2004)
- Residues beyond the selectivity filter of the K+ channel kir2.1 regulate permeation and block by external Rb+ and Cs+. Thompson, G.A., Leyland, M.L., Ashmole, I., Sutcliffe, M.J., Stanfield, P.R. J. Physiol. (Lond.) (2000)
- Functional expression of exogenous proteins in mammalian sensory hair cells infected with adenoviral vectors. Holt, J.R., Johns, D.C., Wang, S., Chen, Z.Y., Dunn, R.J., Marban, E., Corey, D.P. J. Neurophysiol. (1999)
- Knockout blow for channel identity crisis : vasodilation to potassium is mediated via Kir2.1. Sobey, C.G., Faraci, F.M. Circ. Res. (2000)
- Primary structure and functional expression of a mouse inward rectifier potassium channel. Kubo, Y., Baldwin, T.J., Jan, Y.N., Jan, L.Y. Nature (1993)
- Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Yu, C.R., Power, J., Barnea, G., O'Donnell, S., Brown, H.E., Osborne, J., Axel, R., Gogos, J.A. Neuron (2004)
- A region of the muscarinic-gated atrial K+ channel critical for activation by G protein beta gamma subunits. Takao, K., Yoshii, M., Kanda, A., Kokubun, S., Nukada, T. Neuron (1994)
- Targeted disruption of Kir2.1 and Kir2.2 genes reveals the essential role of the inwardly rectifying K(+) current in K(+)-mediated vasodilation. Zaritsky, J.J., Eckman, D.M., Wellman, G.C., Nelson, M.T., Schwarz, T.L. Circ. Res. (2000)
- Multiple promoter elements interact to control the transcription of the potassium channel gene, KCNJ2. Redell, J.B., Tempel, B.L. J. Biol. Chem. (1998)
- Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. Takahashi, N., Morishige, K., Jahangir, A., Yamada, M., Findlay, I., Koyama, H., Kurachi, Y. J. Biol. Chem. (1994)
- Opposite effect of intracellular Ca2+ and protein kinase C on the expression of inwardly rectifying K+ channel 1 in mouse skeletal muscle. Shin, K.S., Park, J.Y., Kwon, H., Chung, C.H., Kang, M.S. J. Biol. Chem. (1997)
- Characterization of inward-rectifier K+ channel inhibition by antiarrhythmic piperazine. Xu, Y., Lu, Z. Biochemistry (2004)
- Modulation of the inward rectifier potassium channel IRK1 by the Ras signaling pathway. Giovannardi, S., Forlani, G., Balestrini, M., Bossi, E., Tonini, R., Sturani, E., Peres, A., Zippel, R. J. Biol. Chem. (2002)
- Inward rectification by polyamines in mouse Kir2.1 channels: synergy between blocking components. Xie, L.H., John, S.A., Weiss, J.N. J. Physiol. (Lond.) (2003)
- Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. Morishige, K., Takahashi, N., Jahangir, A., Yamada, M., Koyama, H., Zanelli, J.S., Kurachi, Y. FEBS Lett. (1994)
- Conduction through the inward rectifier potassium channel, Kir2.1, is increased by negatively charged extracellular residues. D'Avanzo, N., Cho, H.C., Tolokh, I., Pekhletski, R., Tolokh, I., Gray, C., Goldman, S., Backx, P.H. J. Gen. Physiol. (2005)
- The role of a single aspartate residue in ionic selectivity and block of a murine inward rectifier K+ channel Kir2.1. Abrams, C.J., Davies, N.W., Shelton, P.A., Stanfield, P.R. J. Physiol. (Lond.) (1996)
- Transgenic upregulation of IK1 in the mouse heart leads to multiple abnormalities of cardiac excitability. Li, J., McLerie, M., Lopatin, A.N. Am. J. Physiol. Heart Circ. Physiol. (2004)
- AMPA receptor-mediated modulation of inward rectifier K+ channels in astrocytes of mouse hippocampus. Schröder, W., Seifert, G., Hüttmann, K., Hinterkeuser, S., Steinhäuser, C. Mol. Cell. Neurosci. (2002)
- Cloning provides evidence for a family of inward rectifier and G-protein coupled K+ channels in the brain. Lesage, F., Duprat, F., Fink, M., Guillemare, E., Coppola, T., Lazdunski, M., Hugnot, J.P. FEBS Lett. (1994)
- Differential voltage-dependent K+ channel responses during proliferation and activation in macrophages. Vicente, R., Escalada, A., Coma, M., Fuster, G., Sánchez-Tilló, E., López-Iglesias, C., Soler, C., Solsona, C., Celada, A., Felipe, A. J. Biol. Chem. (2003)
- Mutations in the putative pore-forming segment favor short-lived wild-type Kir2.1 pore conformations. Schwalbe, R.A., Wingo, C.S., Xia, S.L. Biochemistry (2002)
- Molecular cloning, functional expression and localization of an inward rectifier potassium channel in the mouse brain. Morishige, K., Takahashi, N., Findlay, I., Koyama, H., Zanelli, J.S., Peterson, C., Jenkins, N.A., Copeland, N.G., Mori, N., Kurachi, Y. FEBS Lett. (1993)
- Upregulation of Kv1.3 K(+) channels in microglia deactivated by TGF-beta. Schilling, T., Quandt, F.N., Cherny, V.V., Zhou, W., Heinemann, U., Decoursey, T.E., Eder, C. Am. J. Physiol., Cell Physiol. (2000)
- Molecular cloning, functional expression and localization of a novel inward rectifier potassium channel in the rat brain. Koyama, H., Morishige, K., Takahashi, N., Zanelli, J.S., Fass, D.N., Kurachi, Y. FEBS Lett. (1994)
- A single aspartate residue is involved in both intrinsic gating and blockage by Mg2+ of the inward rectifier, IRK1. Stanfield, P.R., Davies, N.W., Shelton, P.A., Sutcliffe, M.J., Khan, I.A., Brammar, W.J., Conley, E.C. J. Physiol. (Lond.) (1994)