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Gene Review:

NRXN1 - neurexin 1

Bos taurus

Russell, A.B. et al., Sheckler, L.R. et al., Missler, M. et al., Petrenko, A.G. et al., Ullrich, B. et al.

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High impact information on NRXN1

Neurexophilin was discovered as a neuronal glycoprotein that is copurified with neurexin Ialpha during affinity chromatography on immobilized alpha-latrotoxin (Petrenko et al., 1996) [1].
Our results indicate that neurexin is not expressed at electric organ nerve terminals, as expected by the neurexin hypothesis [2].
Ca2+ binding ceases to be measurable when an 8- or 15-residue splice insert is present at the splice site SS#2 indicating that alternative splicing can affect Ca2+-binding sites of neurexin LNS/LG domains [3].

Anatomical context of NRXN1

Neurexin is expressed on nerves, but not at nerve terminals, in the electric organ [2].

Analytical, diagnostic and therapeutic context of NRXN1

In situ hybridization revealed differential but overlapping distributions of neurexin isoforms in different classes of neurons [4].
Using affinity chromatography on immobilized alpha-latrotoxin, we have purified a novel 29 kDa protein, neurexophilin, in a complex with neurexin l alpha [5].
Specific antibodies generated against the intracellular domain of electric fish neurexin were used in immunocytochemical and Western blot analyses of the electromotor neurons that innervate the electric organ [2].

References

Neurexophilins form a conserved family of neuropeptide-like glycoproteins. Missler, M., Südhof, T.C. J. Neurosci. (1998) [Pubmed]
Neurexin is expressed on nerves, but not at nerve terminals, in the electric organ. Russell, A.B., Carlson, S.S. J. Neurosci. (1997) [Pubmed]
Crystal structure of the second LNS/LG domain from neurexin 1alpha: Ca2+ binding and the effects of alternative splicing. Sheckler, L.R., Henry, L., Sugita, S., Südhof, T.C., Rudenko, G. J. Biol. Chem. (2006) [Pubmed]
Cartography of neurexins: more than 1000 isoforms generated by alternative splicing and expressed in distinct subsets of neurons. Ullrich, B., Ushkaryov, Y.A., Südhof, T.C. Neuron (1995) [Pubmed]
Structure and evolution of neurexophilin. Petrenko, A.G., Ullrich, B., Missler, M., Krasnoperov, V., Rosahl, T.W., Südhof, T.C. J. Neurosci. (1996) [Pubmed]

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