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Gene Review

NXPH1  -  neurexophilin 1

Homo sapiens

Synonyms: NPH1, Nbla00697, Neurexophilin-1
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Disease relevance of NXPH1


High impact information on NXPH1

  • A novel flavoprotein, NPH1, is also implicated in plant phototropism [4].
  • Together our data suggest that neurexophilin constitutes a secreted glycoprotein that is synthesized in a subclass of neurons and may be a ligand for neurexins [5].
  • RNA blots and in situ hybridizations revealed that neurexophilin is expressed in adult rat brain at high levels only in a scattered subpopulation of neurons that probably represent inhibitory interneurons; by contrast, neurexins are expressed in all neurons [5].
  • The search might be over, however, as two photoreceptors, phytochrome and NPH1, have been shown to autophosphorylate in a light-dependent fashion [6].
  • Sensitivity of ts36 to IFN was only the consequence of the point mutation in the NPH-1 gene, as shown by characterization of the rescued virus, R36 [3].


  1. Neurexophilins form a conserved family of neuropeptide-like glycoproteins. Missler, M., Südhof, T.C. J. Neurosci. (1998) [Pubmed]
  2. Neurexophilin binding to alpha-neurexins. A single LNS domain functions as an independently folding ligand-binding unit. Missler, M., Hammer, R.E., Südhof, T.C. J. Biol. Chem. (1998) [Pubmed]
  3. A mutation of the nucleoside triphosphate phosphohydrolase I (NPH-I) gene confers sensitivity of vaccinia virus to interferon. Díaz-Guerra, M., Kahn, J.S., Esteban, M. Virology (1993) [Pubmed]
  4. Seeing the world in red and blue: insight into plant vision and photoreceptors. Ahmad, M. Curr. Opin. Plant Biol. (1999) [Pubmed]
  5. Structure and evolution of neurexophilin. Petrenko, A.G., Ullrich, B., Missler, M., Krasnoperov, V., Rosahl, T.W., Südhof, T.C. J. Neurosci. (1996) [Pubmed]
  6. Light receptor kinases in plants! Fankhauser, C., Chory, J. Curr. Biol. (1999) [Pubmed]
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