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Gene Review

Slco1a4  -  solute carrier organic anion transporter...

Mus musculus

Synonyms: AI785519, Oatp1a4, Oatp2, Slc21a5, Sodium-independent organic anion-transporting polypeptide 2, ...
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High impact information on Slco1a4

  • Tcf1-/- liver has decreased expression of the basolateral membrane bile acid transporters Slc10a1, Slc21a3 and Slc21a5, leading to impaired portal bile acid uptake and elevated plasma bile acid concentrations [1].
  • In Hepa-1c1c7 cells, adenylyl cyclase activator forskolin as well as two cellular membrane-permeable cAMP analogs, dibutyryl cAMP and 8-bromo-cAMP, induced Oatp2 mRNA expression in a time- and dose-dependent manner [2].
  • Luciferase activity driven by the Oatp2 promoter containing this CRE site was induced in cells cotransfected with a plasmid encoding the protein kinase A catalytic subunit [2].
  • These three chemicals induced reporter gene activity in cells transfected with a luciferase reporter gene construct containing a 7.6-kilobase (kb) 5'-flanking region of mouse Oatp2 [2].
  • Bromosulfophthalein (BSP), a substrate not transported by the rat Oatp2, is transported very well by mouse Oatp2 [3].


  1. Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism. Shih, D.Q., Bussen, M., Sehayek, E., Ananthanarayanan, M., Shneider, B.L., Suchy, F.J., Shefer, S., Bollileni, J.S., Gonzalez, F.J., Breslow, J.L., Stoffel, M. Nat. Genet. (2001) [Pubmed]
  2. Activation of cAMP-Dependent Signaling Pathway Induces Mouse Organic Anion Transporting Polypeptide 2 Expression. Chen, C., Cheng, X., Dieter, M.Z., Tanaka, Y., Klaassen, C.D. Mol. Pharmacol. (2007) [Pubmed]
  3. Functional characterization of the mouse organic-anion-transporting polypeptide 2. van Montfoort, J.E., Schmid, T.E., Adler, I.D., Meier, P.J., Hagenbuch, B. Biochim. Biophys. Acta (2002) [Pubmed]
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