The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

Bromthalein     disodium2-hydroxy-5-[4,5,6,7- tetrabromo-1...

Synonyms: Hepartest, Bromsulfan, Bromotaleina, CBSP, Bromsulphalein, ...
This record was replaced with 5345.
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Sulfobromophthalein

  • Since spironolactone treatment was not associated with improvement in the fractional clearance of bromosulfophthalein, nor in serum albumin, prothrombin time, and factor V, the data are compatible with the idea that even in cirrhosis the hepatic drug-oxidizing enzymes were induced by spironolactone [1].
  • In contrast, bromosulfophthalein, a MOAT substrate, had no effect on either E(2)17G-mediated cholestasis or its biliary excretion [2].
  • The kinetics of plasma clearance of indocyanine green and bromosulfophthalein were studied in 49 consecutive patients with chronic unconjugated hyperbilirubinemia [3].
  • These patients were older (p less than 0.02) and, 3 months following bypass, had greater cumulative per cent weight loss (p less than 0.05), higher levels of serum aspartate aminotransferase (p less than 0.005), and greater 45-min bromosulfophthalein retention (p less than 0.02) [4].
  • The other sister (L.R.) had never had symptomatic liver disease and only a slight increase in serum transaminase and bromsulfalein retention [5].

High impact information on Sulfobromophthalein

  • Administration of BSP or probenecid simultaneously with [C14] penicillin resulted in increased plasma retention and reduced kidney and urinary bladder content of [14C] penicillin and a correlation coefficient of -0.8 between total kidney/plasma radioactivity and percent of protein-bound radioactivity bound to ligandin in the kidney [6].
  • ATP-dependent daunomycin transport by brush border vesicles was unidirectional (inside to outside) and temperature dependent and was blocked by Gp170 inhibitors but not by taurocholate or bromsulphalein glutathione [7].
  • Routine tests of liver function and histology were normal, except for a slight increase in bromsulphalein retention (9% at 45 min) [8].
  • Effects of phototherapy on bile acid turnover, biliary lipid concentration, liver function tests, and bromosulfophthalein (BSP) kinetics were studied in 8 alcoholic cirrhotics [9].
  • EE decreased the secretory rate maximum (SRM) of tauroursodeoxycholate, (-71%) and bromosulfophthalein (BSP; -60%), as well as the expression of the BSP canalicular carrier, mrp2; SIL failed to increase mrp2 expression, and had only a marginal beneficial effect on both tauroursodeoxycholate and BSP SRM values [10].

Chemical compound and disease context of Sulfobromophthalein

  • Dubin-Johnson syndrome (DJS), a congenital metabolic disorder of bilirubin excretion, was classically diagnosed by the bromsulfalein (BSP) curve and needle hepatic biopsy methods [11].
  • Patients receiving full doses of doxorubicin with mild hepatic dysfunction as determined by bromsulphalein (BSP) retention and serum liver function studies had the same incidence of toxicity and complete response rate as those with normal hepatic function [12].
  • 5. In summary, rats with arterial calcinosis showed an increase in total body clearance of both BSP and SA, probably associated with modifications in their metabolism and/or in organ extraction [13].

Biological context of Sulfobromophthalein


Anatomical context of Sulfobromophthalein


Associations of Sulfobromophthalein with other chemical compounds


Gene context of Sulfobromophthalein


Analytical, diagnostic and therapeutic context of Sulfobromophthalein

  • No significant change in serum liver function tests or BSP plasma disappearance curves was seen [9].
  • Evaluation immediately after partial hepatectomy revealed a 66% reduction of liver mass, a 63% decrease in hepatocyte bromosulfophthalein removal, and a 65% decline in Kupffer cell carbon phagocytosis [14].
  • The entry and exit kinetic parameters obtained during the perfusion of Gd-BOPTA plus bromosulfophthalein were identical and comparable to those obtained during Gd-DTPA perfusion (P =.95) [32].
  • Enzymes were measured in preservation and reperfusion solutions, and reperfused liver function was evaluated by O(2) consumption and bromsulphalein clearance [33].
  • To investigate the role of sex steroids in the sex-related difference in the hepatic uptake of organic anions, sulphobromophthalein (bromsulphalein, BSP) transport was measured in hepatocytes isolated from rats either deprived of hormonal influence by castration at prepubertal age or after hormonal substitution [34].


  1. Spironolactone and enzyme induction in patients with alcoholic cirrhosis. Miguet, J.P., Vuitton, D., Thebault-Lucas, A., Joanne, C., Dhumeaux, D. Gastroenterology (1980) [Pubmed]
  2. MDR1 substrates/modulators protect against beta-estradiol-17beta-D-glucuronide cholestasis in rat liver. Liu, Y., Huang, L., Hoffman, T., Gosland, M., Vore, M. Cancer Res. (1996) [Pubmed]
  3. A constitutional unconjugated hyperbilirubinemia combined with indocyanine green intolerance: a new functional disorder? Ohkubo, H., Okuda, K., Iida, S. Hepatology (1981) [Pubmed]
  4. Prognostic indicators of hepatic injury following jejunoileal bypass performed for refractory obesity: a prospective study. Haines, N.W., Baker, A.L., Boyer, J.L., Glagov, S., Schneir, H., Jaspan, J., Ferguson, D.J. Hepatology (1981) [Pubmed]
  5. Hepatic disease in erythropoietic protoporphyria. Bloomer, J.R., Phillips, M.J., Davidson, D.L., Klatskin, G., Bloomer, n.u.l.l. Am. J. Med. (1975) [Pubmed]
  6. Structural and functional studies of ligandin, a major renal organic anion-binding protein. Kirsch, R., Fleischner, G., Kamisaka, K., Arias, I.M. J. Clin. Invest. (1975) [Pubmed]
  7. The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa. Hsing, S., Gatmaitan, Z., Arias, I.M. Gastroenterology (1992) [Pubmed]
  8. Fatal liver failure in protoporphyria. Synergism between ethanol excess and the genetic defect. Bonkovsky, H.L., Schned, A.R. Gastroenterology (1986) [Pubmed]
  9. Effects of phototherapy on hepatic function in human alcoholic cirrhosis. Knodell, R.G., Cheney, H., Ostrow, J.D. Gastroenterology (1976) [Pubmed]
  10. Beneficial effects of silymarin on estrogen-induced cholestasis in the rat: a study in vivo and in isolated hepatocyte couplets. Crocenzi, F.A., Sánchez Pozzi, E.J., Pellegrino, J.M., Favre, C.O., Rodríguez Garay, E.A., Mottino, A.D., Coleman, R., Roma, M.G. Hepatology (2001) [Pubmed]
  11. A new diagnostic approach to the Dubin-Johnson syndrome. Pinós, T., Constansa, J.M., Palacin, A., Figueras, C. Am. J. Gastroenterol. (1990) [Pubmed]
  12. Acute doxorubicin toxicity. Relationship to pretreatment liver function, response, and pharmacokinetics in patients with acute nonlymphocytic leukemia. Brenner, D.E., Wiernik, P.H., Wesley, M., Bachur, N.R. Cancer (1984) [Pubmed]
  13. Pharmacokinetics of organic anions in rats with arterial calcinosis. Qualglia, N.B., Hofer, C.G., Torres, A.M. Clin. Exp. Pharmacol. Physiol. (2002) [Pubmed]
  14. Hepatocyte and Kupffer cell functions during liver regeneration in streptozotocin-diabetic rats. Cornell, R.P., Hinck, B.K., Halley, R.E. Hepatology (1981) [Pubmed]
  15. Organic anion transport in HepG2 cells: absence of the high-affinity, chloride-dependent transporter. Min, A.D., Goeser, T., Liu, R., Campbell, C.G., Novikoff, P.M., Wolkoff, A.W. Hepatology (1991) [Pubmed]
  16. Molecular aspects of the interaction of bromosulfophthalein with high-affinity binding sites of bovine serum albumin. Pfaff, E., Schwenk, M., Burr, R., Remmer, H. Mol. Pharmacol. (1975) [Pubmed]
  17. Mutations in the SLCO1B3 gene affecting the substrate specificity of the hepatocellular uptake transporter OATP1B3 (OATP8). Letschert, K., Keppler, D., König, J. Pharmacogenetics (2004) [Pubmed]
  18. Isoform-specific biotransformation of glyceryl trinitrate by rat aortic glutathione S-transferases. Nigam, R., Anderson, D.J., Lee, S.F., Bennett, B.M. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  19. Identification of the bromosulfophthalein-sensitive efflux route for methotrexate as the site of action of vincristine in the vincristine-dependent enhancement of methotrexate uptake in L1210 cells. Henderson, G.B., Tsuji, J.M. Cancer Res. (1988) [Pubmed]
  20. Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. van den Dobbelsteen, D.J., Nobel, C.S., Schlegel, J., Cotgreave, I.A., Orrenius, S., Slater, A.F. J. Biol. Chem. (1996) [Pubmed]
  21. Indomethacin decreases jejunal fluid secretion in addition to luminal release of prostaglandin E2 in patients with acute cholera. Van Loon, F.P., Rabbani, G.H., Bukhave, K., Rask-Madsen, J. Gut (1992) [Pubmed]
  22. Bromosulfophthalein disposition in chronically bile duct obstructed rats. Yaari, A., Sikuler, E., Keynan, A., Ben-Zvi, Z. J. Hepatol. (1992) [Pubmed]
  23. A low molecular weight binding protein for organic anions (Z protein) from human hepatic cytosol: purification and quantitation. Kamisaka, n.u.l.l., Maezawa, H., Inagaki, T., Okano, K. Hepatology (1981) [Pubmed]
  24. The modified dipeptide, enalapril, an angiotensin-converting enzyme inhibitor, is transported by the rat liver organic anion transport protein. Pang, K.S., Wang, P.J., Chung, A.Y., Wolkoff, A.W. Hepatology (1998) [Pubmed]
  25. Impaired organic anion transport in kidney and choroid plexus of organic anion transporter 3 (Oat3 (Slc22a8)) knockout mice. Sweet, D.H., Miller, D.S., Pritchard, J.B., Fujiwara, Y., Beier, D.R., Nigam, S.K. J. Biol. Chem. (2002) [Pubmed]
  26. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Pizzagalli, F., Hagenbuch, B., Stieger, B., Klenk, U., Folkers, G., Meier, P.J. Mol. Endocrinol. (2002) [Pubmed]
  27. Potent inhibition of human folylpolyglutamate synthetase by suramin. McGuire, J.J., Haile, W.H. Arch. Biochem. Biophys. (1996) [Pubmed]
  28. Functional characterization of the mouse organic-anion-transporting polypeptide 2. van Montfoort, J.E., Schmid, T.E., Adler, I.D., Meier, P.J., Hagenbuch, B. Biochim. Biophys. Acta (2002) [Pubmed]
  29. Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Cattori, V., van Montfoort, J.E., Stieger, B., Landmann, L., Meijer, D.K., Winterhalter, K.H., Meier, P.J., Hagenbuch, B. Pflugers Arch. (2001) [Pubmed]
  30. Hydrophobic binding properties of bovine gallbladder mucin. Smith, B.F., LaMont, J.T. J. Biol. Chem. (1984) [Pubmed]
  31. Quantitation of hepatic fatty acid-binding proteins by post-chromatographic ligand binding assay. Morrow, F.D., Martin, R.J. J. Lipid Res. (1983) [Pubmed]
  32. Kinetics of gadobenate dimeglumine in isolated perfused rat liver: MR imaging evaluation. Pastor, C.M., Planchamp, C., Pochon, S., Lorusso, V., Montet, X., Mayer, J., Terrier, F., Vallee, J.P. Radiology. (2003) [Pubmed]
  33. Enzyme release from injured, preserved, and ex vivo reperfused liver does not indicate malfunction. Gioli-Pereira, L., Coradin, K., Nagaoka, M.R., Borges, D.R., Kouyoumdjian, M. Transplantation (2002) [Pubmed]
  34. Sex steroid modulation of the hepatic uptake of organic anions in rat. Persico, M., Bellentani, S., Marchegiano, P., Orzes, N., Lunazzi, G.C., Sottocasa, G.L., Tiribelli, C. J. Hepatol. (1988) [Pubmed]
WikiGenes - Universities