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Chemical Compound Review

Sulfobromophthalein     2-hydroxy-5-[4,5,6,7- tetrabromo-1-(4...

Synonyms: CHEMBL574431, AG-K-07818, CHEBI:63836, CHEBI:672705, CTK5I6051, ...
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Disease relevance of Sulfobromophthalein


High impact information on Sulfobromophthalein


Biological context of Sulfobromophthalein

  • The Gilbert's syndrome patients studied included all three subtypes, as determined from studies of the plasma disappearance kinetics of sulfobromophthalein and indocyanine green [11].
  • Plasma ALDO concentration was positively correlated with plasma renin (p less than 0.001) but not with serum sodium, potassium or albumin concentration, inferior vena cava pressure, corrected hepatic venous wedge pressure, plasma volume or sulfobromophthalein storage or transport [12].
  • In the presence of cholecystographic agents or sulfobromophthalein (BSP), the amount of labeled hormone bound to adsorbent increased in a dose-dependent fashion, reflecting displacement from protein-binding sites [13].
  • METHODS: Parameters of hepatic function (liver biochemistry, indocyanine green and sulfobromophthalein clearances, histology) were analyzed in 170 consecutive adult recipients, who were followed prospectively on the basis of repeat annual work-up [14].
  • Unbound sulfobromophthalein concentration was estimated according to a three binding site model [15].

Anatomical context of Sulfobromophthalein


Associations of Sulfobromophthalein with other chemical compounds


Gene context of Sulfobromophthalein


Analytical, diagnostic and therapeutic context of Sulfobromophthalein


  1. Modification of galactosamine-induced liver injury in rats by reticuloendothelial system stimulation or depression. Al-Tuwaijri, A., Akdamar, K., Di Luzio, N.R. Hepatology (1981) [Pubmed]
  2. Induction of a dose-related increase in sulfobromophthalein uptake velocity in freshly isolated rat hepatocytes by phenobarbital. Potter, B.J., Ni, J.Z., Wolfe, K., Stump, D., Berk, P.D. Hepatology (1994) [Pubmed]
  3. Effects of morphine and respiratory depression on sulfobromophthalein disposition in rats. Hurwitz, A., Fischer, H.R. Anesthesiology (1984) [Pubmed]
  4. Functional changes of the biliary tree associated with experimentally induced cholestasis: sulfobromophthalein on manganese-bilirubin combinations. Dahlström-King, L., Couture, J., Plaa, G.L. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  5. Excretion of sulfobromophthalein in rats with iodomethane-induced depletion of hepatic glutathione. Schulze, P.J., Czok, G., Borck, H.U. Naunyn Schmiedebergs Arch. Pharmacol. (1976) [Pubmed]
  6. Abnormal sulfobromophthalein metabolism in Rotor's syndrome and obligate heterozygotes. Wolpert, E., Pascasio, F.M., Wolkoff, A.W., Arias, I.M. N. Engl. J. Med. (1977) [Pubmed]
  7. Role of chloride and intracellular pH on the activity of the rat hepatocyte organic anion transporter. Min, A.D., Johansen, K.L., Campbell, C.G., Wolkoff, A.W. J. Clin. Invest. (1991) [Pubmed]
  8. Influence of Cl- on organic anion transport in short-term cultured rat hepatocytes and isolated perfused rat liver. Wolkoff, A.W., Samuelson, A.C., Johansen, K.L., Nakata, R., Withers, D.M., Sosiak, A. J. Clin. Invest. (1987) [Pubmed]
  9. Hepatic functional deterioration after portacaval shunt in the rat. Effects on sulfobromophthalein transport-maximum, indocyanine green clearance and galactose elimination capacity. Lauterburg, B.H., Sautter, V., Preisig, R., Bircher, J. Gastroenterology (1976) [Pubmed]
  10. Bilitranslocase and sulfobromophthalein/bilirubin-binding protein are both involved in the hepatic uptake of organic anions. Torres, A.M., Lunazzi, G.C., Stremmel, W., Tiribelli, C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  11. Normal fasting-state levels of serum cholyl-conjugated bile acids in Gilbert's syndrome: an aid to the diagnosis. Vierling, J.M., Berk, P.D., Hofmann, A.F., Martin, J.F., Wolkoff, A.W., Scharschmidt, B.F. Hepatology (1982) [Pubmed]
  12. Plasma levels and hepatic extraction of renin and aldosterone in alcoholic liver disease. Mitch, W.E., Whelton, P.K., Cooke, C.R., Walker, W.G., Maddrey, W.C. Am. J. Med. (1979) [Pubmed]
  13. Effects of cholecystographic agents and sulfobromophthalein on binding of thyroid hormones to serum proteins. Felicetta, J.V., Green, W.L., Huber-Smith, M.J. J. Clin. Endocrinol. Metab. (1983) [Pubmed]
  14. Is acute rejection deleterious to long-term liver allograft function? Dousset, B., Conti, F., Cherruau, B., Louvel, A., Soubrane, O., Houssin, D., Calmus, Y. J. Hepatol. (1998) [Pubmed]
  15. Hepatocellular sulfobromophthalein uptake at physiologic albumin concentrations: kinetic evidence for a high affinity/low capacity sinusoidal membrane system. Sorrentino, D., Bartoli, E. J. Hepatol. (1996) [Pubmed]
  16. Immunological studies of an organic anion-binding protein isolated from rat liver cell plasma membrane. Wolkoff, A.W., Sosiak, A., Greenblatt, H.C., Van Renswoude, J., Stockert, R.J. J. Clin. Invest. (1985) [Pubmed]
  17. Hepatobiliary effects of morphine are mediated in the brain. Hurwitz, A., Looney, G., Sullins, M., Ben-Zvi, Z. Hepatology (1990) [Pubmed]
  18. Subunit composition, organic anion binding, catalytic and immunological properties of ligandin from rat testis. Bhargava, M.M., Ohmi, N., Listowsky, I., Arias, I.M. J. Biol. Chem. (1980) [Pubmed]
  19. Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line. Brigle, K.E., Spinella, M.J., Sierra, E.E., Goldman, I.D. J. Biol. Chem. (1995) [Pubmed]
  20. Norepinephrine-induced cholestasis in the isolated perfused rat liver is secondary to its hemodynamic effects. Lenzen, R., Funk, A., Kolb-Bachofen, V., Strohmeyer, G. Hepatology (1990) [Pubmed]
  21. The human organic anion transport protein SLC21A6 is not sufficient for bilirubin transport. Wang, P., Kim, R.B., Chowdhury, J.R., Wolkoff, A.W. J. Biol. Chem. (2003) [Pubmed]
  22. Multiple canalicular transport mechanisms for glutathione S-conjugates. Transport on both ATP- and voltage-dependent carriers. Ballatori, N., Truong, A.T. J. Biol. Chem. (1995) [Pubmed]
  23. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. König, J., Cui, Y., Nies, A.T., Keppler, D. J. Biol. Chem. (2000) [Pubmed]
  24. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. König, J., Cui, Y., Nies, A.T., Keppler, D. Am. J. Physiol. Gastrointest. Liver Physiol. (2000) [Pubmed]
  25. Inhibitors of ATP-binding cassette transporters suppress interleukin-12 p40 production and major histocompatibility complex II up-regulation in macrophages. Haskó, G., Deitch, E.A., Németh, Z.H., Kuhel, D.G., Szabó, C. J. Pharmacol. Exp. Ther. (2002) [Pubmed]
  26. Induction of ornithine decarboxylase and S-adenosylmethionine decarboxylase by sulfobromophthalein in rats. Oguro, T., Numazawa, S., Yoshida, T., Kuroiwa, Y. Life Sci. (1989) [Pubmed]
  27. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. Cha, S.H., Sekine, T., Kusuhara, H., Yu, E., Kim, J.Y., Kim, D.K., Sugiyama, Y., Kanai, Y., Endou, H. J. Biol. Chem. (2000) [Pubmed]
  28. Distinguishing between folate receptor-alpha-mediated transport and reduced folate carrier-mediated transport in L1210 leukemia cells. Spinella, M.J., Brigle, K.E., Sierra, E.E., Goldman, I.D. J. Biol. Chem. (1995) [Pubmed]
  29. Abnormal hepatic uptake of low doses of sulfobromophthalein in Gilbert's syndrome: the role of reduced affinity of the plasma membrane carrier of organic anions. Gentile, S., Persico, M., Tiribelli, C. Hepatology (1990) [Pubmed]
  30. Difference in the effects of ursodeoxycholate and its taurine conjugate on the biliary excretion of sulfobromophthalein in the rat. Kanai, S., Kitani, K., Sato, Y. J. Hepatol. (1990) [Pubmed]
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