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Gene Review

GSDMA  -  gasdermin A

Homo sapiens

Synonyms: FKSG9, FLJ39120, GSDM, GSDM1, Gasdermin-1, ...
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High impact information on GSDM1

  • Here, we compared human GSDML-GSDM locus with rodent genomes by using bioinformatics [1].
  • Rat Gsdm gene was identified within rat genome clone CH230-28N16 (AC119462.4), and was mapped to rat chromosome 10q31 [1].
  • Rat Gsdm gene, consisting of 12 exons, encoded a 446-amino-acid protein, which showed 86.3% and 32.3% total-amino-acid identities with human GSDM and GSDML, respectively [1].
  • The MGC9753-ERBB2-MGC14832-GRB7-ZNFN1A3-ZPBPL-PRO2521-ORMDL3-GSDM locus on human chromosome 17q12-q21 and the ZPBP-ZNFN1A1-FIGNL1-DDC-GRB10-COBL-SEC61G-EGFR-LANCL2 locus on human chromosome 7p12-p11 were next compared [2].

Regulatory relationships of GSDM1


  1. Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
  2. Identification and characterization of human ZPBP-like gene in silico. Katoh, M., Katoh, M. Int. J. Mol. Med. (2003) [Pubmed]
  3. GASDERMIN, suppressed frequently in gastric cancer, is a target of LMO1 in TGF-beta-dependent apoptotic signalling. Saeki, N., Kim, D.H., Usui, T., Aoyagi, K., Tatsuta, T., Aoki, K., Yanagihara, K., Tamura, M., Mizushima, H., Sakamoto, H., Ogawa, K., Ohki, M., Shiroishi, T., Yoshida, T., Sasaki, H. Oncogene (2007) [Pubmed]
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