Gene Review:
LMO1 - LIM domain only 1 (rhombotin 1)
Homo sapiens
Synonyms:
Cysteine-rich protein TTG-1, LIM domain only protein 1, LMO-1, RBTN1, RHOM1, ...
- SCL and LMO1 alter thymocyte differentiation: inhibition of E2A-HEB function and pre-T alpha chain expression. Herblot, S., Steff, A.M., Hugo, P., Aplan, P.D., Hoang, T. Nat. Immunol. (2000)
- OLIG2 (BHLHB1), a bHLH transcription factor, contributes to leukemogenesis in concert with LMO1. Lin, Y.W., Deveney, R., Barbara, M., Iscove, N.N., Nimer, S.D., Slape, C., Aplan, P.D. Cancer Res. (2005)
- Mutational analysis of the LMO4 gene, encoding a BRCA1-interacting protein, in breast carcinomas. Sutherland, K.D., Visvader, J.E., Choong, D.Y., Sum, E.Y., Lindeman, G.J., Campbell, I.G. Int. J. Cancer (2003)
- Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Ferrando, A.A., Neuberg, D.S., Staunton, J., Loh, M.L., Huard, C., Raimondi, S.C., Behm, F.G., Pui, C.H., Downing, J.R., Gilliland, D.G., Lander, E.S., Golub, T.R., Look, A.T. Cancer Cell (2002)
- Cysteine-rich LIM domains of LIM-homeodomain and LIM-only proteins contain zinc but not iron. Archer, V.E., Breton, J., Sanchez-Garcia, I., Osada, H., Forster, A., Thomson, A.J., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1994)
- LMO T-cell translocation oncogenes typify genes activated by chromosomal translocations that alter transcription and developmental processes. Rabbitts, T.H. Genes Dev. (1998)
- Signaling routes to CREM and CREB: plasticity in transcriptional activation. De Cesare, D., Fimia, G.M., Sassone-Corsi, P. Trends Biochem. Sci. (1999)
- An scl gene product lacking the transactivation domain induces bony abnormalities and cooperates with LMO1 to generate T-cell malignancies in transgenic mice. Aplan, P.D., Jones, C.A., Chervinsky, D.S., Zhao, X., Ellsworth, M., Wu, C., McGuire, E.A., Gross, K.W. EMBO J. (1997)
- The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins. Wadman, I.A., Osada, H., Grütz, G.G., Agulnick, A.D., Westphal, H., Forster, A., Rabbitts, T.H. EMBO J. (1997)
- The LMO1 AND LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11). Valge-Archer, V., Forster, A., Rabbitts, T.H. Oncogene (1998)
- Characterization of the Lmo4 gene encoding a LIM-only protein: genomic organization and comparative chromosomal mapping. Tse, E., Grutz, G., Garner, A.A., Ramsey, Y., Carter, N.P., Copeland, N., Gilbert, D.J., Jenkins, N.A., Agulnick, A., Forster, A., Rabbitts, T.H. Mamm. Genome (1999)
- Molecular cloning of LMO41, a new human LIM domain gene. Racevskis, J., Dill, A., Sparano, J.A., Ruan, H. Biochim. Biophys. Acta (1999)
- Development and characterization of T cell leukemia cell lines established from SCL/LMO1 double transgenic mice. Chervinsky, D.S., Lam, D.H., Zhao, X.F., Melman, M.P., Aplan, P.D. Leukemia (2001)
- Transcriptional activity of TAL1 in T cell acute lymphoblastic leukemia (T-ALL) requires RBTN1 or -2 and induces TALLA1, a highly specific tumor marker of T-ALL. Ono, Y., Fukuhara, N., Yoshie, O. J. Biol. Chem. (1997)
- The LIM domain-only protein LMO4 is required for neural tube closure. Lee, S.K., Jurata, L.W., Nowak, R., Lettieri, K., Kenny, D.A., Pfaff, S.L., Gill, G.N. Mol. Cell. Neurosci. (2005)
- Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. Chan, K.K., Tsui, S.K., Lee, S.M., Luk, S.C., Liew, C.C., Fung, K.P., Waye, M.M., Lee, C.Y. Gene (1998)
- LIM-only protein, CRP2, switched on smooth muscle gene activity in adult cardiac myocytes. Chang, D.F., Belaguli, N.S., Chang, J., Schwartz, R.J. Proc. Natl. Acad. Sci. U.S.A. (2007)
- The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Tu, Y., Li, F., Goicoechea, S., Wu, C. Mol. Cell. Biol. (1999)
- LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1. Osada, H., Grutz, G.G., Axelson, H., Forster, A., Rabbitts, T.H. Leukemia (1997)
- Molecular Mechanisms for Transcriptional Regulation of Human High-Affinity IgE Receptor beta-Chain Gene Induced by GM-CSF. Takahashi, K., Hayashi, N., Kaminogawa, S., Ra, C. J. Immunol. (2006)
- The rhombotin gene family encode related LIM-domain proteins whose differing expression suggests multiple roles in mouse development. Foroni, L., Boehm, T., White, L., Forster, A., Sherrington, P., Liao, X.B., Brannan, C.I., Jenkins, N.A., Copeland, N.G., Rabbitts, T.H. J. Mol. Biol. (1992)
- The LIM-only protein LMO4 modulates the transcriptional activity of HEN1. Manetopoulos, C., Hansson, A., Karlsson, J., Jönsson, J.I., Axelson, H. Biochem. Biophys. Res. Commun. (2003)
- The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells. Valge-Archer, V.E., Osada, H., Warren, A.J., Forster, A., Li, J., Baer, R., Rabbitts, T.H. Proc. Natl. Acad. Sci. U.S.A. (1994)