Gene Review:
RUNX3 - runt-related transcription factor 3
Homo sapiens
Synonyms:
AML2, Acute myeloid leukemia 2 protein, CBF-alpha-3, CBFA3, Core-binding factor subunit alpha-3, ...
Oshimura,
S. Kin,
Yoshikawa,
T. Okanoue,
Chiba,
Ogino,
Adachi,
Ito,
H. Yamagishi,
Kin,
Yamagishi,
Yoshida,
H. Ida,
Giles,
Basic,
K.I. Fukuda,
Nakase,
Quintás-Cardama,
Nakada,
T. Yoshikawa,
Manshouri,
Sakakura,
Y. Ito,
Loda,
A. Hagiwara,
Verstovsek,
Miyagawa,
C. Sakakura,
Orsolic,
Kirkner,
Golemovic,
Fuchs,
Sato,
Hagiwara,
Scappini,
Chandra,
Ogawa,
T. Chiba,
Yazumi,
Moriyama,
Nakashima,
Kantarjian,
K. Ito,
Ito,
Takeda,
Osaki,
K. Miyagawa,
Kawasaki,
S. Nakashima,
Adachi,
Komori,
Y. Nakase,
Inoue,
Ito,
S. Yazumi,
- RUNX3 suppresses gastric epithelial cell growth by inducing p21(WAF1/Cip1) expression in cooperation with transforming growth factor {beta}-activated SMAD. Chi, X.Z., Yang, J.O., Lee, K.Y., Ito, K., Sakakura, C., Li, Q.L., Kim, H.R., Cha, E.J., Lee, Y.H., Kaneda, A., Ushijima, T., Kim, W.J., Ito, Y., Bae, S.C. Mol. Cell. Biol. (2005)
- RUNX3 is frequently inactivated by dual mechanisms of protein mislocalization and promoter hypermethylation in breast cancer. Lau, Q.C., Raja, E., Salto-Tellez, M., Liu, Q., Ito, K., Inoue, M., Putti, T.C., Loh, M., Ko, T.K., Huang, C., Bhalla, K.N., Zhu, T., Ito, Y., Sukumar, S. Cancer Res. (2006)
- Transcriptional cross-regulation of RUNX1 by RUNX3 in human B cells. Spender, L.C., Whiteman, H.J., Karstegl, C.E., Farrell, P.J. Oncogene (2005)
- RUNX3 Inhibits the Expression of Vascular Endothelial Growth Factor and Reduces the Angiogenesis, Growth, and Metastasis of Human Gastric Cancer. Peng, Z., Wei, D., Wang, L., Tang, H., Zhang, J., Le, X., Jia, Z., Li, Q., Xie, K. Clin. Cancer Res. (2006)
- TGFBR2 mutation is correlated with CpG island methylator phenotype in microsatellite instability-high colorectal cancer. Ogino, S., Kawasaki, T., Ogawa, A., Kirkner, G.J., Loda, M., Fuchs, C.S. Hum. Pathol. (2007)
- Frequent silencing of RUNX3 in esophageal squamous cell carcinomas is associated with radioresistance and poor prognosis. Sakakura, C., Miyagawa, K., Fukuda, K.I., Nakashima, S., Yoshikawa, T., Kin, S., Nakase, Y., Ida, H., Yazumi, S., Yamagishi, H., Okanoue, T., Chiba, T., Ito, K., Hagiwara, A., Ito, Y. Oncogene (2007)
- Causal relationship between the loss of RUNX3 expression and gastric cancer. Li, Q.L., Ito, K., Sakakura, C., Fukamachi, H., Inoue, K., Chi, X.Z., Lee, K.Y., Nomura, S., Lee, C.W., Han, S.B., Kim, H.M., Kim, W.J., Yamamoto, H., Yamashita, N., Yano, T., Ikeda, T., Itohara, S., Inazawa, J., Abe, T., Hagiwara, A., Yamagishi, H., Ooe, A., Kaneda, A., Sugimura, T., Ushijima, T., Bae, S.C., Ito, Y. Cell (2002)
- Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells. Djuretic, I.M., Levanon, D., Negreanu, V., Groner, Y., Rao, A., Ansel, K.M. Nat. Immunol. (2007)
- "Runx"ing towards sensory differentiation. Zhong, J., Pevny, L., Snider, W.D. Neuron (2006)
- Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cord. Chen, A.I., de Nooij, J.C., Jessell, T.M. Neuron (2006)
- Epigenetic inactivation of RUNX3 in microsatellite unstable sporadic colon cancers. Goel, A., Arnold, C.N., Tassone, P., Chang, D.K., Niedzwiecki, D., Dowell, J.M., Wasserman, L., Compton, C., Mayer, R.J., Bertagnolli, M.M., Boland, C.R. Int. J. Cancer (2004)
- Tumor suppressor gene Runx3 sensitizes gastric cancer cells to chemotherapeutic drugs by downregulating Bcl-2, MDR-1 and MRP-1. Guo, C., Ding, J., Yao, L., Sun, L., Lin, T., Song, Y., Sun, L., Fan, D. Int. J. Cancer (2005)
- Therapy-related acute myeloid leukemia with t(8;21) in a child with previous Ewing's sarcoma. Lesesve, J.F., Schneider, P., Dolgopolov, I., Bastard, C., Lenormand, B., Cambon-Michot, E., Callat, M.P., Cavelier, B., Tron, P.H., Vannier, J.P. Med. Pediatr. Oncol. (1997)
- Isolation and characterization of daunorubicin-resistant AML-2 sublines. Choi, C.H., Ling, V. Mol. Cells (1997)
- Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Orsolic, N., Golemovic, M., Quintás-Cardama, A., Scappini, B., Manshouri, T., Chandra, J., Basic, I., Giles, F., Kantarjian, H., Verstovsek, S. Cancer Sci. (2006)
- Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. Jin, Y.H., Jeon, E.J., Li, Q.L., Lee, Y.H., Choi, J.K., Kim, W.J., Lee, K.Y., Bae, S.C. J. Biol. Chem. (2004)
- Role of RUNX family members in transcriptional repression and gene silencing. Durst, K.L., Hiebert, S.W. Oncogene (2004)
- Frequent downregulation of the runt domain transcription factors RUNX1, RUNX3 and their cofactor CBFB in gastric cancer. Sakakura, C., Hagiwara, A., Miyagawa, K., Nakashima, S., Yoshikawa, T., Kin, S., Nakase, Y., Ito, K., Yamagishi, H., Yazumi, S., Chiba, T., Ito, Y. Int. J. Cancer (2005)
- Expression of RUNX3 protein in human gastric mucosa, intestinal metaplasia and carcinoma. Osaki, M., Moriyama, M., Adachi, K., Nakada, C., Takeda, A., Inoue, Y., Adachi, H., Sato, K., Oshimura, M., Ito, H. Eur. J. Clin. Invest. (2004)
- RUNX3 regulates the activity of the CD11a and CD49d integrin gene promoters. Domínguez-Soto, A., Relloso, M., Vega, M.A., Corbí, A.L., Puig-Kröger, A. Immunobiology (2005)
- Promoter hypermethylation downregulates RUNX3 gene expression in colorectal cancer cell lines. Ku, J.L., Kang, S.B., Shin, Y.K., Kang, H.C., Hong, S.H., Kim, I.J., Shin, J.H., Han, I.O., Park, J.G. Oncogene (2004)
- Epigenetic inactivation of the RUNX3 gene in lung cancer. Sato, K., Tomizawa, Y., Iijima, H., Saito, R., Ishizuka, T., Nakajima, T., Mori, M. Oncol. Rep. (2006)
- Quantitative assessment of RUNX3 methylation in neoplastic and non-neoplastic gastric epithelia using a DNA microarray. So, K., Tamura, G., Honda, T., Homma, N., Endoh, M., Togawa, N., Nishizuka, S., Motoyama, T. Pathol. Int. (2006)
- How does the human RUNX3 gene induce apoptosis in gastric cancer? Latest data, reflections and reactions. Vogiatzi, P., De Falco, G., Claudio, P.P., Giordano, A. Cancer Biol. Ther. (2006)
- Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Calpha promoter. Hanai, J., Chen, L.F., Kanno, T., Ohtani-Fujita, N., Kim, W.Y., Guo, W.H., Imamura, T., Ishidou, Y., Fukuchi, M., Shi, M.J., Stavnezer, J., Kawabata, M., Miyazono, K., Ito, Y. J. Biol. Chem. (1999)
- RUNX expression and function in human B cells. Whiteman, H.J., Farrell, P.J. Crit. Rev. Eukaryot. Gene Expr. (2006)
- RUNX3 negatively regulates CD36 expression in myeloid cell lines. Puig-Kröger, A., Domínguez-Soto, A., Martínez-Muñoz, L., Serrano-Gómez, D., Lopez-Bravo, M., Sierra-Filardi, E., Fernández-Ruiz, E., Ruiz-Velasco, N., Ardavín, C., Groner, Y., Tandon, N., Corbí, A.L., Vega, M.A. J. Immunol. (2006)
- Inactivation of p16, RUNX3, and HPP1 occurs early in Barrett's-associated neoplastic progression and predicts progression risk. Schulmann, K., Sterian, A., Berki, A., Yin, J., Sato, F., Xu, Y., Olaru, A., Wang, S., Mori, Y., Deacu, E., Hamilton, J., Kan, T., Krasna, M.J., Beer, D.G., Pepe, M.S., Abraham, J.M., Feng, Z., Schmiegel, W., Greenwald, B.D., Meltzer, S.J. Oncogene (2005)
- Role of Runx proteins in chondrogenesis. Yoshida, C.A., Komori, T. Crit. Rev. Eukaryot. Gene Expr. (2005)
- Enhancer of zeste homologue 2 (EZH2) down-regulates RUNX3 by increasing histone H3 methylation. Fujii, S., Ito, K., Ito, Y., Ochiai, A. J. Biol. Chem. (2008)
- Expression status of RUNX1/AML1 in normal gastric epithelium and its mutational analysis in microdissected gastric cancer cells. Usui, T., Aoyagi, K., Saeki, N., Nakanishi, Y., Kanai, Y., Ohki, M., Ogawa, K., Yoshida, T., Sasaki, H. Int. J. Oncol. (2006)
- Phylogenesis and regulated expression of the RUNT domain transcription factors RUNX1 and RUNX3. Levanon, D., Glusman, G., Bettoun, D., Ben-Asher, E., Negreanu, V., Bernstein, Y., Harris-Cerruti, C., Brenner, O., Eilam, R., Lotem, J., Fainaru, O., Goldenberg, D., Pozner, A., Woolf, E., Xiao, C., Yarmus, M., Groner, Y. Blood Cells Mol. Dis. (2003)
- An important role for RUNX3 in human L1 transcription and retrotransposition. Yang, N., Zhang, L., Zhang, Y., Kazazian, H.H. Nucleic Acids Res. (2003)