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Gene Review

tfdS  -  ORF33

Ralstonia eutropha JMP134

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Disease relevance of tfdS


High impact information on tfdS

  • Expression of tfdR and tfdS, the (identical) regulatory genes for the tfd pathway remained low and essentially unchanged during the entire adaptation phase [2].
  • In vivo recombinants of pYG1010 and a cloned tfdS gene rescued the 2,4-D phenotype, indicating that TfdS is a positive regulator of tfdA expression, but not for tfdCDEF expression [3].
  • Regulation of these operons by two unlinked genes, tfdR and tfdS, has been proposed [3].
  • The DNA sequence reveals 100% identify with the regulatory gene tfdS of pJP4 [1].

Biological context of tfdS

  • Physical and DNA sequence analyses revealed that the tfdR and tfdS genes were identical and were located within a longer inverted repeat of 1592 bp [3].
  • One reason why the tfd(II) genes do not disappear from plasmid pJP4 might be the necessity for keeping the regulatory genes for the 2,4-D pathway expression tfdR and tfdS [4].

Analytical, diagnostic and therapeutic context of tfdS

  • Sequence analysis of pJP4-F3 indicated that the plasmid had undergone a deletion of approximately 16 kb, which included the tfdA-tfdS intergenic region, spanning the tfdA gene to a previously unreported IS1071 element [5].


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