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Gene Review

tfdR  -  ORF30

Ralstonia eutropha JMP134

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Disease relevance of tfdR


High impact information on tfdR

  • Expression of tfdR and tfdS, the (identical) regulatory genes for the tfd pathway remained low and essentially unchanged during the entire adaptation phase [3].
  • The deduced amino acid sequence of tfdR indicates that it is a member of the LysR-type activators [4].
  • Regulation of these operons by two unlinked genes, tfdR and tfdS, has been proposed [4].
  • One reason why the tfd(II) genes do not disappear from plasmid pJP4 might be the necessity for keeping the regulatory genes for the 2,4-D pathway expression tfdR and tfdS [1].
  • The tfdR gene product can successfully take over the role of the insertion element-inactivated TfdT protein as a transcriptional activator of the tfdCDEF gene cluster, which encodes chlorocatechol degradation in Ralstonia eutropha JMP134(pJP4) [5].

Biological context of tfdR

  • The deduced amino acid sequence of the incomplete ORF, situated divergently from tfdR, indicates similarity to chloromuconate cycloisomerases produced by genes tfdD and tcbD of plasmids pJP4 and pP51, respectively [2].
  • Physical and DNA sequence analyses revealed that the tfdR and tfdS genes were identical and were located within a longer inverted repeat of 1592 bp [4].

Analytical, diagnostic and therapeutic context of tfdR


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