The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

ilvG  -  pseudo

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3760, JW3740, JW3741, ilvO
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of ilvG

  • Transducing phages excised from these fusion strains with and without the ilvO determinant were compared [1].
  • Physical location of the ilvO determinant in Escherichia coli K-12 deoxyribonucleic acid [2].

High impact information on ilvG

  • The effect of the ilvG671, ilvG468, and ilvG603 mutations (phenotype, IlvG+ Valr; formerly ilvO) upon proteins synthesized was determined by infection of irradiated Escherichia coli K-12 cells, using specifically constructed derivatives of lambda dilv phage [3].
  • This fragment carries a small amount of the promoter-proximal end of ilvE, the ilvO determinant, and apparently the entire ilvG gene, which specifies the valine-insensitive acetohydroxy acid synthase [2].
  • The introduction of an ilvO mutation allowed the ilvG gene of the plasmid to be expressed and imparted valine resistance to strains carrying it [4].
  • In two of the valine-resistant strains, the ilvG mutations were on the rbs side of ilvO, indicating a gene order rbs-ilvG-ilvO-ilvE-ilvD-ilvA-ilvC [5].
  • The expression of the ilvOEDA operon is stimulated 2-fold when the hisT76 mutation is present in strains containing either ilvO- or rho221 mutations [6].

Chemical compound and disease context of ilvG


Biological context of ilvG

  • A plasmid carrying the 4,6-kilobase (kb) HindIII-derived fragment from an ilvO mutant derivative of lambda h80dilv imparted a valine-resistant phenotype on strains it carried [2].
  • The model involves multiple attentuation sites and a possible role for the ilvO locus which lies at the distal end of the ilvEDA operon (but is not part of it) [7].

Other interactions of ilvG

  • Reexamination of the earlier studied ilvO lesion revealed that it, too, lies between ilvE and rbs [5].


  1. Location of the multivalent control site for the ilvEDA operon of Escherichia coli. Gayda, D.J., Leathers, T.D., Noti, J.D., Smith, F.J., Smith, J.M., Subrahmanyam, C.S., Umbarger, H.E. J. Bacteriol. (1980) [Pubmed]
  2. Physical location of the ilvO determinant in Escherichia coli K-12 deoxyribonucleic acid. Subrahmanyam, C.S., McCorkle, G.M., Umbarger, H.E. J. Bacteriol. (1980) [Pubmed]
  3. Identification of a protein of 15,000 daltons related to isoleucine-valine biosynthesis in Escherichia coli K-12. Gray, J.E., Wallen, J.W., Calhoun, D.H. J. Bacteriol. (1982) [Pubmed]
  4. Regulation of ilvEDA expression occurs upstream of ilvG in Escherichia coli: additional evidence for an ilvGEDA operon. Subrahmanyam, C.S., Noti, J.D., Umbarger, H.E. J. Bacteriol. (1980) [Pubmed]
  5. Mutations affecting the formation of acetohydroxy acid synthase II in Escherichia coli K-12. Smith, J.M., Smith, F.J., Umbarger, H.E. Mol. Gen. Genet. (1979) [Pubmed]
  6. A site of action for tRNA mediated regulation of the ilvOEDA operon of Escherichia coli K12. Lawther, R.P., Hatfield, G.W. Mol. Gen. Genet. (1978) [Pubmed]
  7. Polarity and the regulation of the ilv gene cluster in Escherichia coli strain K-12. Smith, J.M., Smolin, D.E., Umbarger, H.E. Mol. Gen. Genet. (1976) [Pubmed]
WikiGenes - Universities