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Gene Review:

aroK - shikimate kinase I

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK3377, JW5947

Johansson, L. et al., Griffin, H.G. et al., Løbner-Olesen, A. et al., Løbner-Olesen, A. et al., Katayama, T. et al., et al.

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Disease relevance of aroK

Identification of the gene (aroK) encoding shikimic acid kinase I of Escherichia coli [1].

High impact information on aroK

Three of the suppressors carried Tn5 in the aroK or aroB gene, the first two cistrons in the dam operon [2].
The reason for this difference is interpreted in terms of starvation for aromatic amino acids under carbon-limitation which is relieved under phosphate-limitation due to an upregulation of aroK and aroA [3].
The translational start point of aroK is some 84 bp downstream of the site proposed earlier and the reading frame ends 169 bp beyond the stop site reported in the previous sequence [4].

Biological context of aroK

This 16 kDa open reading frame has been identified as aroK, the gene for shikimic acid kinase I. Thus the dam gene is part of an operon containing aroK, aroB, urf74.3, and dam [5].
An open reading frame coding for an aroK homologue is located immediately upstream of aroB [6].

Associations of aroK with chemical compounds

We propose that urf1 encodes shikimate kinase I and that it be designated aroK [1].

References

Identification of the gene (aroK) encoding shikimic acid kinase I of Escherichia coli. Løbner-Olesen, A., Marinus, M.G. J. Bacteriol. (1992) [Pubmed]
Overinitiation of chromosome replication in the Escherichia coli dnaAcos mutant depends on activation of oriC function by the dam gene product. Katayama, T., Akimitsu, N., Mizushima, T., Miki, T., Sekimizu, K. Mol. Microbiol. (1997) [Pubmed]
Transcriptome analysis of a shikimic acid producing strain of Escherichia coli W3110 grown under carbon- and phosphate-limited conditions. Johansson, L., Lid??n, G. J. Biotechnol. (2006) [Pubmed]
The gene (aroK) encoding shikimate kinase I from Escherichia coli. Griffin, H.G., Gasson, M.J. DNA Seq. (1995) [Pubmed]
Expression of the Escherichia coli dam gene. Løbner-Olesen, A., Boye, E., Marinus, M.G. Mol. Microbiol. (1992) [Pubmed]
Cloning and characterisation of the Neisseria gonorrhoeae aroB gene. Barten, R., Meyer, T.F. Mol. Gen. Genet. (1998) [Pubmed]

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