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Gene Review

aroA  -  5-enolpyruvylshikimate-3-phosphate synthetase

Escherichia coli str. K-12 substr. MG1655

Synonyms: ECK0899, JW0891
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Disease relevance of aroA


High impact information on aroA


Chemical compound and disease context of aroA


Biological context of aroA

  • The reason for this difference is interpreted in terms of starvation for aromatic amino acids under carbon-limitation which is relieved under phosphate-limitation due to an upregulation of aroK and aroA [10].
  • The phenotype of the relB mutants is accentuated by amber suppressors, and this effect is counteracted by a mutation, pus-1 that maps at 19.5 min near aroA [11].
  • Salmonella typhimurium strain SL3261, an attenuated aroA vaccine strain, was used as a carrier for the plasmid pXY411, which directs the expression of GZ in salmonellae (which do not normally produce this protein) [7].

Associations of aroA with chemical compounds


Other interactions of aroA

  • Moreover, when expressed in attenuated aroA S. typhimurium strain SL3261, the plasmids carrying malE and malE-HIV genes were stable in vitro and in vivo [13].


  1. Characterization of Streptococcus pneumoniae 5-enolpyruvylshikimate 3-phosphate synthase and its activation by univalent cations. Du, W., Wallis, N.G., Mazzulla, M.J., Chalker, A.F., Zhang, L., Liu, W.S., Kallender, H., Payne, D.J. Eur. J. Biochem. (2000) [Pubmed]
  2. Bacteriophage P22 as a vehicle for transducing cosmid gene banks between smooth strains of Salmonella typhimurium: use in identifying a role for aroD in attenuating virulent Salmonella strains. Miller, I.A., Chatfield, S., Dougan, G., Desilva, L., Joysey, H.S., Hormaeche, C. Mol. Gen. Genet. (1989) [Pubmed]
  3. Direct expression of Bordetella pertussis filamentous hemagglutinin in Escherichia coli and Salmonella typhimurium aroA. Guzmán, C.A., Walker, M.J., Rohde, M., Timmis, K.N. Infect. Immun. (1991) [Pubmed]
  4. Sequencing and expression of the aroA gene from Dichelobacter nodosus. Alm, R.A., Dalrymple, B.P., Mattick, J.S. Gene (1994) [Pubmed]
  5. Cloning and characterization of the aroA gene from Mycobacterium tuberculosis. Garbe, T., Jones, C., Charles, I., Dougan, G., Young, D. J. Bacteriol. (1990) [Pubmed]
  6. Uptake of pathogenic intracellular bacteria into human and murine macrophages downregulates the eukaryotic 26S protease complex ATPase gene. Schwan, W.R., Kopecko, D.J. Infect. Immun. (1997) [Pubmed]
  7. An attenuated aroA Salmonella typhimurium vaccine elicits humoral and cellular immunity to cloned beta-galactosidase in mice. Brown, A., Hormaeche, C.E., Demarco de Hormaeche, R., Winther, M., Dougan, G., Maskell, D.J., Stocker, B.A. J. Infect. Dis. (1987) [Pubmed]
  8. Amplification of the aroA gene from Escherichia coli results in tolerance to the herbicide glyphosate. Rogers, S.G., Brand, L.A., Holder, S.B., Sharps, E.S., Brackin, M.J. Appl. Environ. Microbiol. (1983) [Pubmed]
  9. Construction of a safe, stable, efficacious vaccine against Photobacterium damselae ssp. piscicida. Thune, R.L., Fernandez, D.H., Hawke, J.P., Miller, R. Dis. Aquat. Org. (2003) [Pubmed]
  10. Transcriptome analysis of a shikimic acid producing strain of Escherichia coli W3110 grown under carbon- and phosphate-limited conditions. Johansson, L., Lid??n, G. J. Biotechnol. (2006) [Pubmed]
  11. Variations in phenotype of relB mutants of Escherichia coli and the effect of pus and sup mutations. Diderichsen, B., Desmarez, L. Mol. Gen. Genet. (1980) [Pubmed]
  12. Expression of a bacterial aroA mutant, aroA-M1, encoding 5-enolpyruvylshikimate-3-phosphate synthase for the production of glyphosate-resistant tobacco plants. Wang, H.Y., Li, Y.F., Xie, L.X., Xu, P. J. Plant Res. (2003) [Pubmed]
  13. Studies of the anaerobically induced promoter pnirB and the improved expression of bacterial antigens. Newton, S.M., Klebba, P.E., Hofnung, M., Charbit, A. Res. Microbiol. (1995) [Pubmed]
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