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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TRDV1  -  T cell receptor delta variable 1

Homo sapiens

Synonyms: hDV101S1
 
 
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High impact information on TRDV1

  • The TRDV1-BCL11B joining region was 1344 bp long and contained fragments derived from 20q11.22, 3p21.33 and from 11p12, indicating the complex character of this aberration [1].
  • All germline TRDV1 genes present a high degree of similarity in their coding as well as in 5' and 3' flanking regions [2].
  • Molecular cloning of cDNA from gamma/delta T cells has shown that in sheep, the variable domain of the delta chain is chiefly determined by the expression of the TRDV1 subgroup, apparently composed of a large number of genes [2].
  • Some are TRDV1 genes also found in peripheral blood lymphocytes, while four genes had not been described so far [3].
  • cDNA sequences obtained from polymerase chain reaction products of reverse-transcribed RNA from sheep thymus showed the presence of a large number of members of the TRDV1 gene family [3].

References

  1. Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL. Przybylski, G.K., Dik, W.A., Wanzeck, J., Grabarczyk, P., Majunke, S., Martin-Subero, J.I., Siebert, R., Dölken, G., Ludwig, W.D., Verhaaf, B., van Dongen, J.J., Schmidt, C.A., Langerak, A.W. Leukemia (2005) [Pubmed]
  2. Artiodactyl emergence is accompanied by the birth of an extensive pool of diverse germline TRDV1 genes. Antonacci, R., Lanave, C., Del Faro, L., Vaccarelli, G., Ciccarese, S., Massari, S. Immunogenetics (2005) [Pubmed]
  3. Genomic organization of sheep TRDJ segments and their expression in the delta-chain repertoire in thymus. Massari, S., Antonacci, R., Lanave, C., Ciccarese, S. Immunogenetics (2000) [Pubmed]
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