Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

dag1 - dystroglycan 1

Danio rerio

Synonyms: SO:0000704, dag, wu:fb83d06, wu:fi25f06, wu:fi37b08, ...

Parsons, M.J. et al., Guyon, J.R. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of dag1

Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos [1].

High impact information on dag1

Expression of the sarcoglycans, dystroglycan and dystrophin has been confirmed by western blotting [2].
In addition, knowing the dystroglycan null phenotype in zebrafish will facilitate the isolation of other molecules involved in muscular dystrophy pathogenesis [1].
Dystroglycan or the DGC is also required for normal sarcomere and sarcoplasmic reticulum organisation [1].
In contrast to mouse, where dystroglycan mutations lead to peri-implantation lethality, dystroglycan is dispensable for basement membrane formation during early zebrafish development [1].

References

Removal of dystroglycan causes severe muscular dystrophy in zebrafish embryos. Parsons, M.J., Campos, I., Hirst, E.M., Stemple, D.L. Development (2002) [Pubmed]
The dystrophin associated protein complex in zebrafish. Guyon, J.R., Mosley, A.N., Zhou, Y., O'Brien, K.F., Sheng, X., Chiang, K., Davidson, A.J., Volinski, J.M., Zon, L.I., Kunkel, L.M. Hum. Mol. Genet. (2003) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

DAG1	Bos taurus
DAG1	Canis lupus familiaris
DAG1	Gallus gallus
DAG1	Homo sapiens
DAG1	Macaca mulatta
Dag1	Mus musculus
DAG1	Pan troglodytes
Dag1	Rattus norvegicus
dag1	Xenopus (Silurana) tropicalis

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.