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Gene Review

DAG1  -  dystroglycan 1 (dystrophin-associated...

Homo sapiens

Synonyms: 156DAG, A3a, AGRNR, DAG, Dystroglycan, ...
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Disease relevance of DAG1


High impact information on DAG1


Biological context of DAG1


Anatomical context of DAG1


Associations of DAG1 with chemical compounds


Physical interactions of DAG1


Other interactions of DAG1


Analytical, diagnostic and therapeutic context of DAG1

  • Single base polymorphism in the DAG1 gene detected by DGGE and mismatch PCR [27].
  • For the measurement of phosphoinositide turnover after intravenous injection of DAG, dynamic PET data were collected continuously for 46 min [5].
  • Polymerase chain reaction and northern blot analysis have shown both H. armigera A3a and A3b genes are expressed during pupal development and in the brain of newly enclosed adults [28].
  • In comparison with the control groups, all biomaterials (PLLA, PGPD, and collagen I/III) showed a significant increase in local Ca(2+) accumulation under DAG stimulation after 28 days in vitro [29].
  • Concomitantly, the significant enhancement of the level of DAG and AA radioactivity at this short reperfusion time confirmed the active PI degradation by phospholipase(s) in cerebral cortex and hippocampus [30].


  1. Deficiency of the 50K dystrophin-associated glycoprotein in severe childhood autosomal recessive muscular dystrophy. Matsumura, K., Tomé, F.M., Collin, H., Azibi, K., Chaouch, M., Kaplan, J.C., Fardeau, M., Campbell, K.P. Nature (1992) [Pubmed]
  2. Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. Ibraghimov-Beskrovnaya, O., Ervasti, J.M., Leveille, C.J., Slaughter, C.A., Sernett, S.W., Campbell, K.P. Nature (1992) [Pubmed]
  3. Both hypertrophic and dilated cardiomyopathies are caused by mutation of the same gene, delta-sarcoglycan, in hamster: an animal model of disrupted dystrophin-associated glycoprotein complex. Sakamoto, A., Ono, K., Abe, M., Jasmin, G., Eki, T., Murakami, Y., Masaki, T., Toyo-oka, T., Hanaoka, F. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  4. Dystroglycan loss disrupts polarity and {beta}-casein induction in mammary epithelial cells by perturbing laminin anchoring. Weir, M.L., Oppizzi, M.L., Henry, M.D., Onishi, A., Campbell, K.P., Bissell, M.J., Muschler, J.L. J. Cell. Sci. (2006) [Pubmed]
  5. Evaluation of phosphoinositide turnover on ischemic human brain with 1-[1-11C]-butyryl-2-palmitoyl-rac-glycerol using PET. Matsumoto, K., Imahori, Y., Fujii, R., Ohmori, Y., Sekimoto, T., Ueda, S., Mineura, K. J. Nucl. Med. (1999) [Pubmed]
  6. Brief report: deficiency of a dystrophin-associated glycoprotein (adhalin) in a patient with muscular dystrophy and cardiomyopathy. Fadic, R., Sunada, Y., Waclawik, A.J., Buck, S., Lewandoski, P.J., Campbell, K.P., Lotz, B.P. N. Engl. J. Med. (1996) [Pubmed]
  7. Primary adhalinopathy: a common cause of autosomal recessive muscular dystrophy of variable severity. Piccolo, F., Roberds, S.L., Jeanpierre, M., Leturcq, F., Azibi, K., Beldjord, C., Carrié, A., Récan, D., Chaouch, M., Reghis, A. Nat. Genet. (1995) [Pubmed]
  8. Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy. Noguchi, S., McNally, E.M., Ben Othmane, K., Hagiwara, Y., Mizuno, Y., Yoshida, M., Yamamoto, H., Bönnemann, C.G., Gussoni, E., Denton, P.H., Kyriakides, T., Middleton, L., Hentati, F., Ben Hamida, M., Nonaka, I., Vance, J.M., Kunkel, L.M., Ozawa, E. Science (1995) [Pubmed]
  9. Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization. Ibraghimov-Beskrovnaya, O., Milatovich, A., Ozcelik, T., Yang, B., Koepnick, K., Francke, U., Campbell, K.P. Hum. Mol. Genet. (1993) [Pubmed]
  10. Single nucleotide polymorphisms in the dystroglycan gene do not correlate with disease severity in hereditary inclusion body myopathy. Gottlieb, E., Ciccone, C., Darvish, D., Naiem-Cohen, S., Dalakas, M.C., Savelkoul, P.J., Krasnewich, D.M., Gahl, W.A., Huizing, M. Mol. Genet. Metab. (2005) [Pubmed]
  11. Cellular adjustment of gastric cancer for hepatic metastasis in successive orthotopic implantation model. Shen, X., Jin, W., Cui, H., Cui, X., Noh, S., Chung, H., Lin, Z. Cancer Biol. Ther. (2006) [Pubmed]
  12. Rapid effects of 1,25(OH)2 vitamin D3 on signal transduction systems in colonic cells. Sitrin, M.D., Bissonnette, M., Bolt, M.J., Wali, R., Khare, S., Scaglione-Sewell, B., Skarosi, S., Brasitus, T.A. Steroids (1999) [Pubmed]
  13. Dystrophin and the dystrophin-associated glycoprotein, beta-dystroglycan, co-localize in photoreceptor synaptic complexes of the human retina. Drenckhahn, D., Holbach, M., Ness, W., Schmitz, F., Anderson, L.V. Neuroscience (1996) [Pubmed]
  14. Transduction of myogenic cells by retargeted dual high-capacity hybrid viral vectors: robust dystrophin synthesis in duchenne muscular dystrophy muscle cells. Gonçalves, M.A., Holkers, M., Cudré-Mauroux, C., van Nierop, G.P., Knaän-Shanzer, S., van der Velde, I., Valerio, D., de Vries, A.A. Mol. Ther. (2006) [Pubmed]
  15. A dystrophin-associated glycoprotein, A3a (one of 43DAG doublets), is retained in Duchenne muscular dystrophy muscle. Yoshida, M., Mizuno, Y., Nonaka, I., Ozawa, E. J. Biochem. (1993) [Pubmed]
  16. Ultrastructure of diaphragm from dystrophic alpha-sarcoglycan-null mice. Jakubiec-Puka, A., Biral, D., Krawczyk, K., Betto, R. Acta Biochim. Pol. (2005) [Pubmed]
  17. Tumor necrosis factor induces rapid production of 1'2'diacylglycerol by a phosphatidylcholine-specific phospholipase C. Schütze, S., Berkovic, D., Tomsing, O., Unger, C., Krönke, M. J. Exp. Med. (1991) [Pubmed]
  18. Theoretical studies on electron delocalization in diaminoguanidine. Bharatam, P.V., Iqbal, P. Journal of computational chemistry. (2006) [Pubmed]
  19. Involvement of second messengers in regulation of the low-density lipoprotein receptor gene. Auwerx, J.H., Chait, A., Wolfbauer, G., Deeb, S.S. Mol. Cell. Biol. (1989) [Pubmed]
  20. Membrane current induced by protein kinase C activators in rhabdomeric photoreceptors: implications for visual excitation. del Pilar Gomez, M., Nasi, E. J. Neurosci. (1998) [Pubmed]
  21. Formation of the neuromuscular junction. Agrin and its unusual receptors. Hoch, W. Eur. J. Biochem. (1999) [Pubmed]
  22. Differential expression of dystrophin, utrophin and dystrophin-associated proteins in peripheral nerve. Matsumura, K., Yamada, H., Shimizu, T., Campbell, K.P. FEBS Lett. (1993) [Pubmed]
  23. Adhalin deficiency: an unusual cause of muscular dystrophy. Dua, T., Kalra, V., Sharma, M.C., Kabra, M. Indian journal of pediatrics. (2001) [Pubmed]
  24. Absence of gamma-sarcoglycan (35 DAG) in autosomal recessive muscular dystrophy linked to chromosome 13q12. Jung, D., Leturcq, F., Sunada, Y., Duclos, F., Tomé, F.M., Moomaw, C., Merlini, L., Azibi, K., Chaouch, M., Slaughter, C., Fardeau, M., Kaplan, J.C., Campbell, K.P. FEBS Lett. (1996) [Pubmed]
  25. 2-Arylidenedihydroindole-3-ones: Design, synthesis, and biological activity on bladder carcinoma cell lines. Gerby, B., Boumendjel, A., Blanc, M., Bringuier, P.P., Champelovier, P., Fortun??, A., Ronot, X., Boutonnat, J. Bioorg. Med. Chem. Lett. (2007) [Pubmed]
  26. Dag-1 carcinoma cell in studying the mechanisms of progression and therapeutic resistance in bladder cancer. Champelovier, P., Besse, A., Boucard, N., Simon, A., Leroux, D., Pinel, N., Praloran, V., Seigneurin, D. Eur. Urol. (2001) [Pubmed]
  27. Single base polymorphism in the DAG1 gene detected by DGGE and mismatch PCR. Ibraghimov-Beskrovnaya, O., Sheffield, V.C., Campbell, K.P. Hum. Mol. Genet. (1993) [Pubmed]
  28. Evidence for gene conversion between tandemly duplicated cytoplasmic actin genes of Helicoverpa armigera (Lepidoptera:Noctuidae). Rourke, I.J., East, P.D. J. Mol. Evol. (1997) [Pubmed]
  29. Proliferation and osteogenic differentiation of mesenchymal stem cells cultured onto three different polymers in vitro. Jäger, M., Feser, T., Denck, H., Krauspe, R. Annals of biomedical engineering. (2005) [Pubmed]
  30. Alteration of phosphoinositide degradation by cytosolic and membrane-bound phospholipases after forebrain ischemia-reperfusion in gerbil: effects of amyloid beta peptide. Strosznajder, J., Zambrzycka, A., Kacprzak, M.D., Kopczuk, D., Strosznajder, R.P. Neurochem. Res. (1999) [Pubmed]
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