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Gene Review

Dag1  -  dystroglycan 1 (dystrophin-associated...

Rattus norvegicus

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Disease relevance of Dag1


High impact information on Dag1


Biological context of Dag1


Anatomical context of Dag1


Associations of Dag1 with chemical compounds


Physical interactions of Dag1

  • Thus, the present results also support the hypothesis that dystrophin interacts with dystroglycan in cerebellar Purkinje neurons [14].

Other interactions of Dag1


Analytical, diagnostic and therapeutic context of Dag1


  1. Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae. Rambukkana, A., Yamada, H., Zanazzi, G., Mathus, T., Salzer, J.L., Yurchenco, P.D., Campbell, K.P., Fischetti, V.A. Science (1998) [Pubmed]
  2. Processing of beta-dystroglycan by matrix metalloproteinase disrupts the link between the extracellular matrix and cell membrane via the dystroglycan complex. Yamada, H., Saito, F., Fukuta-Ohi, H., Zhong, D., Hase, A., Arai, K., Okuyama, A., Maekawa, R., Shimizu, T., Matsumura, K. Hum. Mol. Genet. (2001) [Pubmed]
  3. A role of dystroglycan in schwannoma cell adhesion to laminin. Matsumura, K., Chiba, A., Yamada, H., Fukuta-Ohi, H., Fujita, S., Endo, T., Kobata, A., Anderson, L.V., Kanazawa, I., Campbell, K.P., Shimizu, T. J. Biol. Chem. (1997) [Pubmed]
  4. Dystroglycan expression in hepatic stellate cells: role in liver fibrosis. Bedossa, P., Ferlicot, S., Paradis, V., Dargère, D., Bonvoust, F., Vidaud, M. Lab. Invest. (2002) [Pubmed]
  5. Disruption of dystroglycan axis by beta-dystroglycan processing in cardiomyopathic hamster muscle. Matsumura, K., Arai, K., Zhong, D., Saito, F., Fukuta-Ohi, H., Maekawa, R., Yamada, H., Shimizu, T. Neuromuscul. Disord. (2003) [Pubmed]
  6. Targeting Schwann cells by nonlytic arenaviral infection selectively inhibits myelination. Rambukkana, A., Kunz, S., Min, J., Campbell, K.P., Oldstone, M.B. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  7. Expression of agrin, dystroglycan, and utrophin in normal renal tissue and in experimental glomerulopathies. Raats, C.J., van den Born, J., Bakker, M.A., Oppers-Walgreen, B., Pisa, B.J., Dijkman, H.B., Assmann, K.J., Berden, J.H. Am. J. Pathol. (2000) [Pubmed]
  8. Podocyte flattening and disorder of glomerular basement membrane are associated with splitting of dystroglycan-matrix interaction. Kojima, K., Davidovits, A., Poczewski, H., Langer, B., Uchida, S., Nagy-Bojarski, K., Hovorka, A., Sedivy, R., Kerjaschki, D. J. Am. Soc. Nephrol. (2004) [Pubmed]
  9. Dystroglycan is involved in laminin-1-stimulated motility of Müller glial cells: combined velocity and directionality analysis. Méhes, E., Czirók, A., Hegedüs, B., Szabó, B., Vicsek, T., Satz, J., Campbell, K., Jancsik, V. Glia (2005) [Pubmed]
  10. Laminin-6 assembles into multimolecular fibrillar complexes with perlecan and participates in mechanical-signal transduction via a dystroglycan-dependent, integrin-independent mechanism. Jones, J.C., Lane, K., Hopkinson, S.B., Lecuona, E., Geiger, R.C., Dean, D.A., Correa-Meyer, E., Gonzales, M., Campbell, K., Sznajder, J.I., Budinger, S. J. Cell. Sci. (2005) [Pubmed]
  11. Dystroglycan is present in rat thyroid and rat thyroid cells and responds to thyrotropin. Collins, B.J., Gorelick, G., Schneider, A.B. Endocrinology (2001) [Pubmed]
  12. The alpha-dystroglycan-beta-dystroglycan complex. Membrane organization and relationship to an agrin receptor. Deyst, K.A., Bowe, M.A., Leszyk, J.D., Fallon, J.R. J. Biol. Chem. (1995) [Pubmed]
  13. Laminin-induced aggregation of the inwardly rectifying potassium channel, Kir4.1, and the water-permeable channel, AQP4, via a dystroglycan-containing complex in astrocytes. Guadagno, E., Moukhles, H. Glia (2004) [Pubmed]
  14. Dystroglycan in the cerebellum is a laminin alpha 2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells. Tian, M., Jacobson, C., Gee, S.H., Campbell, K.P., Carbonetto, S., Jucker, M. Eur. J. Neurosci. (1996) [Pubmed]
  15. Dystrophins in neurohypophysial lobe of normal and dehydrated rats: immunolocalization and biochemical characterization. Dorbani-Mamine, L., Stoeckel, M.E., Jancsik, V., Ayad, G., Rendon, A. Neuroreport (1998) [Pubmed]
  16. High-fat feeding period affects gene expression in rat white adipose tissue. Lopez, I.P., Milagro, F.I., Marti, A., Moreno-Aliaga, M.J., Martinez, J.A., De Miguel, C. Mol. Cell. Biochem. (2005) [Pubmed]
  17. N-terminal alpha-dystroglycan binds to different extracellular matrix molecules expressed in regenerating peripheral nerves in a protein-mediated manner and promotes neurite extension of PC12 cells. Hall, H., Bozic, D., Michel, K., Hubbell, J.A. Mol. Cell. Neurosci. (2003) [Pubmed]
  18. Axotomy of sympathetic neurons activates the metalloproteinase-2 enzymatic pathway. Leone, L., De Stefano, M.E., Del Signore, A., Petrucci, T.C., Paggi, P. J. Neuropathol. Exp. Neurol. (2005) [Pubmed]
  19. Immunodetection of partially glycosylated isoforms of alpha-dystroglycan by a new monoclonal antibody against its beta-dystroglycan-binding epitope. Pavoni, E., Sciandra, F., Barca, S., Giardina, B., Petrucci, T.C., Brancaccio, A. FEBS Lett. (2005) [Pubmed]
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