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EIF4G2  -  eukaryotic translation initiation factor 4...

Bos taurus

 
 
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High impact information on EIF4G2

  • A monoclonal antibody to p97 localizes the protein to the cytoplasm and the nuclear envelope. p97 is extracted from nuclear envelopes under the same conditions as the O-glycosylated nucleoporins indicating a tight association with the pore complex [1].
  • Immunodepletion of p97 renders the cytosol inactive for import and identifies at least three other cytosolic proteins that interact with p97. cDNA cloning of p97 shows that it is a unique protein containing 23 cysteine residues [1].
  • Modification of p97 with N-ethylmaleimide (NEM) decreases binding to the pore, but interestingly, NEM treatment of the NLS receptor does not [2].
  • The import was ATP-dependent and inhibited by wheat germ agglutinin or by an antibody against p97, a component of the nuclear import system [3].
  • For p97 we could show a downregulation after stimulation with SNP, bFGF and PDGF-BB but not PDGF-AA [4].
 

Anatomical context of EIF4G2

  • Recombinant p97 binds zinc and a bound metal ion is required for the nuclear envelope binding activity of the protein [1].

References

  1. Sequence and characterization of cytoplasmic nuclear protein import factor p97. Chi, N.C., Adam, E.J., Adam, S.A. J. Cell Biol. (1995) [Pubmed]
  2. Identification of cytosolic factors required for nuclear location sequence-mediated binding to the nuclear envelope. Adam, E.J., Adam, S.A. J. Cell Biol. (1994) [Pubmed]
  3. Nucleolar protein B23 stimulates nuclear import of the HIV-1 Rev protein and NLS-conjugated albumin. Szebeni, A., Mehrotra, B., Baumann, A., Adam, S.A., Wingfield, P.T., Olson, M.O. Biochemistry (1997) [Pubmed]
  4. Differential gene expression of vascular smooth muscle cells. Detection by RNA arbitrarily primed polymerase chain reaction. Alfke, H., Stumm, G., Schnieder, I., Klose, K.J., Schlegel, J. VASA (1999) [Pubmed]
 
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