Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Prss30 - protease, serine, 30

Rattus norvegicus

Synonyms: Disp, Distal intestinal serine protease, Serine protease 30, TMSP-1, Tmprss8, ...

Okumura, Y. et al., Behrens, M. et al., Hobson, J.P. et al., Kunii, D. et al., Wu, Q.

Behrens, Bufe, Schmale, Meyerhof, Wu,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tmprss8

We report the identification and functional analysis of a type II transmembrane serine protease encoded by the mouse differentially expressed in squamous cell carcinoma (DESC) 1 gene, and the definition of a cluster of seven homologous DESC1-like genes within a 0.5-Mb region of mouse chromosome 5E1 [1].

High impact information on Tmprss8

We also demonstrate that a C-terminally truncated variant of TMSP-1 significantly activates the epithelial sodium channel, and that its mRNA levels are upregulated by aldosterone [2].
The amino acid sequence deduced from a full-length cDNA revealed that transmembrane serine protease-1 (TMSP-1) is a member of the clan SA/family S1 of serine proteases, comprising a 30 amino acid prepropeptide, a mature form sequence of 274 amino acids starting with the Ile-Val-Gly-Gly-Gln motif, and a common catalytic triad of serine proteases [2].
In the present study we purified the MGST1 activating protease from liver microsomes and finally identified that the protease is hepsin, a type II transmembrane serine protease [3].

Anatomical context of Tmprss8

Hepsin is a type II transmembrane serine protease abundantly expressed on the surface of hepatocytes [4].

Analytical, diagnostic and therapeutic context of Tmprss8

Molecular cloning and characterisation of DESC4, a new transmembrane serine protease [5].

References

Mouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexes. Hobson, J.P., Netzel-Arnett, S., Szabo, R., Réhault, S.M., Church, F.C., Strickland, D.K., Lawrence, D.A., Antalis, T.M., Bugge, T.H. J. Biol. Chem. (2004) [Pubmed]
Cloning and characterization of a transmembrane-type serine protease from rat kidney, a new sodium channel activator. Okumura, Y., Nishikawa, M., Cui, P., Shiota, M., Nakamura, Y., Adachi, M., Kitamura, K., Tomita, K., Kido, H. Biol. Chem. (2003) [Pubmed]
Purification of liver serine protease which activates microsomal glutathione s-transferase: possible involvement of hepsin. Kunii, D., Shimoji, M., Nakama, S., Ikebe, M., Hachiman, T., Sato, I., Tamaki, A., Yamazaki, K., Aniya, Y. Biol. Pharm. Bull. (2006) [Pubmed]
Gene targeting in hemostasis. Hepsin. Wu, Q. Front. Biosci. (2001) [Pubmed]
Molecular cloning and characterisation of DESC4, a new transmembrane serine protease. Behrens, M., Bufe, B., Schmale, H., Meyerhof, W. Cell. Mol. Life Sci. (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

CG7432	Drosophila melanogaster
LOC697965	Macaca mulatta
Prss30	Mus musculus
LOC750142	Pan troglodytes

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.