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Gene Review

MGST1  -  microsomal glutathione S-transferase 1

Homo sapiens

Synonyms: GST12, MGST, MGST-I, Microsomal GST-1, Microsomal GST-I, ...
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Disease relevance of MGST1


High impact information on MGST1


Biological context of MGST1


Anatomical context of MGST1


Associations of MGST1 with chemical compounds


Other interactions of MGST1


Analytical, diagnostic and therapeutic context of MGST1


  1. Colocalization of leukotriene C synthase and microsomal glutathione S-transferase elucidated by indirect immunofluorescence analysis. Surapureddi, S., Svartz, J., Magnusson, K.E., Hammarström, S., Söderström, M. FEBS Lett. (2000) [Pubmed]
  2. Human melanoma cells generate leukotrienes B4 and C4 from leukotriene A4. Okano-Mitani, H., Ikai, K., Imamura, S. Arch. Dermatol. Res. (1997) [Pubmed]
  3. The three-dimensional map of microsomal glutathione transferase 1 at 6 A resolution. Schmidt-Krey, I., Mitsuoka, K., Hirai, T., Murata, K., Cheng, Y., Fujiyoshi, Y., Morgenstern, R., Hebert, H. EMBO J. (2000) [Pubmed]
  4. Induction of catalase, alpha, and microsomal glutathione S-transferase in CYP2E1 overexpressing HepG2 cells and protection against short-term oxidative stress. Marí, M., Cederbaum, A.I. Hepatology (2001) [Pubmed]
  5. Structural organization of the microsomal glutathione S-transferase gene (MGST1) on chromosome 12p13.1-13.2. Identification of the correct promoter region and demonstration of transcriptional regulation in response to oxidative stress. Kelner, M.J., Bagnell, R.D., Montoya, M.A., Estes, L.A., Forsberg, L., Morgenstern, R. J. Biol. Chem. (2000) [Pubmed]
  6. Microsomal GST-I: genomic organization, expression, and alternative splicing of the human gene. Lee, S.H., DeJong, J. Biochim. Biophys. Acta (1999) [Pubmed]
  7. Catalog of 46 single-nucleotide polymorphisms (SNPs) in the microsomal glutathione S-transferase 1 (MGST1) gene. Iida, A., Saito, S., Sekine, A., Harigae, S., Osawa, S., Mishima, C., Kondo, K., Kitamura, Y., Nakamura, Y. J. Hum. Genet. (2001) [Pubmed]
  8. The gene for the microsomal glutathione S-transferase is on human chromosome 12. DeJong, J.L., Mohandas, T., Tu, C.P. Genomics (1990) [Pubmed]
  9. Human umbilical vein endothelial cells generate leukotriene C4 via microsomal glutathione S-transferase type 2 and express the CysLT(1) receptor. Sjöström, M., Jakobsson, P.J., Heimburger, M., Palmblad, J., Haeggström, J.Z. Eur. J. Biochem. (2001) [Pubmed]
  10. Biotransformation of glyceryl trinitrate by rat hepatic microsomal glutathione S-transferase 1. Ji, Y., Bennett, B.M. J. Pharmacol. Exp. Ther. (2006) [Pubmed]
  11. Further evidence that rat liver microsomal glutathione transferase 1 is not a cellular protein target for S-nitrosylation. Shi, Q., Chen, H.F., Lou, Y.J. Chem. Biol. Interact. (2006) [Pubmed]
  12. Microsomal glutathione S-transferase is the predominant leukotriene C4 binding site in cellular membranes. Metters, K.M., Sawyer, N., Nicholson, D.W. J. Biol. Chem. (1994) [Pubmed]
  13. Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily. Jakobsson, P.J., Morgenstern, R., Mancini, J., Ford-Hutchinson, A., Persson, B. Am. J. Respir. Crit. Care Med. (2000) [Pubmed]
  14. Basal expression of the human MAPEG members microsomal glutathione transferase 1 and prostaglandin E synthase genes is mediated by Sp1 and Sp3. Ekström, L., Lyrenäs, L., Jakobsson, P.J., Morgenstern, R., Kelner, M.J. Biochim. Biophys. Acta (2003) [Pubmed]
  15. Identification and characterization of a novel human microsomal glutathione S-transferase with leukotriene C4 synthase activity and significant sequence identity to 5-lipoxygenase-activating protein and leukotriene C4 synthase. Jakobsson, P.J., Mancini, J.A., Ford-Hutchinson, A.W. J. Biol. Chem. (1996) [Pubmed]
  16. Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities. Jakobsson, P.J., Mancini, J.A., Riendeau, D., Ford-Hutchinson, A.W. J. Biol. Chem. (1997) [Pubmed]
  17. Genetic analysis of the glutathione s-transferase genes MGST1, GSTM3, GSTT1, and GSTM1 in patients with hereditary pancreatitis. Schneider, A., Tögel, S., Barmada, M.M., Whitcomb, D.C. J. Gastroenterol. (2004) [Pubmed]
  18. Protein-protein interaction affinity chromatography of leukotriene C4 synthase. Söderström, M., Morgenstern, R., Hammarström, S. Protein Expr. Purif. (1995) [Pubmed]
  19. Cytosolic and microsomal glutathione S-transferase isoenzymes in normal human liver and intestinal epithelium. Hayes, P.C., Harrison, D.J., Bouchier, I.A., McLellan, L.I., Hayes, J.D. Gut (1989) [Pubmed]
  20. Potent induction of phase 2 enzymes in human prostate cells by sulforaphane. Brooks, J.D., Paton, V.G., Vidanes, G. Cancer Epidemiol. Biomarkers Prev. (2001) [Pubmed]
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