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Gene Review

Eif5a  -  eukaryotic translation initiation factor 5A

Rattus norvegicus

Synonyms: Eukaryotic initiation factor 5A isoform 1, Eukaryotic translation initiation factor 5A-1, eIF-4D, eIF-5A, eIF-5A-1, ...
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Disease relevance of Eif5a


High impact information on Eif5a


Biological context of Eif5a

  • Further, these data suggest that suppression of modified eIF-5A formation is one mechanism by which cells may be induced to undergo apoptosis [4].

Associations of Eif5a with chemical compounds


Other interactions of Eif5a

  • Hypusine is selectively formed in the eukaryotic translation initiation factor eIF-4D, by a post-translational mechanism involving spermidine [Cooper, Park, Folk, Safer & Braverman (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 1854-1857] [1].


  1. Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells. Gerner, E.W., Mamont, P.S., Bernhardt, A., Siat, M. Biochem. J. (1986) [Pubmed]
  2. Deoxyhypusine synthase from rat testis: purification and characterization. Wolff, E.C., Lee, Y.B., Chung, S.I., Folk, J.E., Park, M.H. J. Biol. Chem. (1995) [Pubmed]
  3. Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD. Wolff, E.C., Park, M.H., Folk, J.E. J. Biol. Chem. (1990) [Pubmed]
  4. Excess putrescine accumulation inhibits the formation of modified eukaryotic initiation factor 5A (eIF-5A) and induces apoptosis. Tome, M.E., Fiser, S.M., Payne, C.M., Gerner, E.W. Biochem. J. (1997) [Pubmed]
  5. Hypusine formation in protein by a two-step process in cell lysates. Murphey, R.J., Gerner, E.W. J. Biol. Chem. (1987) [Pubmed]
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