Disease relevance of S-3151

• S. imperator is estimated to have grown to a maximum body length of at least 11 to 12 meters and body weight of about 8 metric tons over a life-span of 50 to 60 years [1].
• We have previously shown that in some patients with primary hyperoxaluria type 1 (PH1), disease is associated with mistargeting of the normally peroxisomal enzyme alanine/glyoxylate aminotransferase (AGT) to mitochondria (Danpure, C.J., P.J. Cooper, P.J. Wise, and P.R. Jennings. J. Cell Biol. 108:1345-1352) [2].
• Previous biochemical analysis of Escherichia coli methyl-directed mismatch repair implicates three redundant single-strand DNA-specific exonucleases (RecJ, ExoI, and ExoVII) and at least one additional unknown exonuclease in the excision reaction (Cooper, D. L., Lahue, R. S., and Modrich, P. (1993) J. Biol. Chem. 268, 11823-11829) [3].
• Furthermore, it is not known whether transfected adenylyl cyclases might display the strict requirement for capacitative Ca2+ entry that is shown by the Ca(2+)-inhibitable ACVI, which is indigenous to C6-2B glioma cells (Chiono, M., Mahey, R., Tate, G., and Cooper, D. M. F. (1995) J. Biol. Chem. 270, 1149-1155) [4].
• Cloning and cleavage site mapping of DNA from bovine herpesvirus 1 (Cooper strain) [5].

Psychiatry related information on S-3151

• Increased glutamate-mediated excitotoxicity seems to play an important role in the pathogenesis of Huntington's disease (Tabrizi, S. J., Cleeter, M. W., Xuereb, J., Taaman, J. W., Cooper, J. M., and Schapira, A. H. (1999) Ann. Neurol. 45, 25-32) [6].
• Medical histories, physical examinations, and blood tests were obtained at Cooper Clinic, Dallas, Texas, from 3,250 men aged 26-83 years (mean, 51 years) without erectile dysfunction at their first visit, who had one more clinic visit, all between 1987 and 1991 [7].
• This article presents the findings from part of a panel presentation on available data sets at the 2001 Cooper Conference on Innovative Approaches to Understanding and Influencing Physical Activity [8].
• CONCLUSION: Since Agocha & Cooper have shown that the likelihood of intentions to engage in risky sex increases as the facial attractiveness of the potential sexual partner increases, through the opposite-sex enhancement effect we identify a new possible link between risky sex and alcohol consumption [9].
• In a semi-intact preparation of Aplysia californica Cooper, classical conditioning training leads to changes in the synaptic strength at the sensory-motor neurone synapse [10].

High impact information on S-3151

• In addition, Cooper and co-workers have reported the detection and isolation of specific oncogenes, B-lym and T-lym, which appear to be activated in human and rodent tumours of certain B and T lymphoid cells, respectively [11].
• Recently, Finkel and Cooper reported that p21 in extracts of human bladder carcinoma cells is involved in a molecular complex with the transferrin receptor of these cells [12].
• A birthday for B cells: Lymphopoiesis II, a scientific symposium honoring Max Cooper [13].
• Cell lines corresponding to more mature adrenal medullary cells expressed IGF-II, and one, SK-N-AS, grows by an IGF-II autocrine mechanism (J. Clin. Invest. 84:829-839) El-Badry, Romanus, Helman, Cooper, Rechler, and Israel. 1989 [14].
• Katz and B. A. Cooper (J Clin Invest 54:733-739, 1974), the authors have observed a dose-related, reversible reduction in the quantity of intrinsic factor-vitamin B12 (IF-B12) receptor (from 5.78 ng to 1.3 ng of B12 binding) in the intestinal mucosa of guinea pigs fed 0.05-0.25 mg/100 g colchicine/day for 3 days [15].

Chemical compound and disease context of S-3151

• We investigated the occurrence of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]-resistant osteomalacia in the New World primate colony of Saguinus imperator at the Los Angeles Zoo. The mean serum concentration of 1,25-(OH)2D3 was elevated 5-fold in the New World primates compared to that in their Old World counterparts [16].
• Parvaquone (Clexon Cooper) was clinically tested for efficacy as a treatment for East Coast Fever (Theileria parva parva infection) in naturally infected cattle [17].
• Permethrin 5% cream (Elimite; Herbert, Irvine, CA) is now considered to be the treatment of choice for infants and small children with scabies because of its high efficacy and low risk of side effects [18].
• The use of the Cooper Permalens soft contact lens as an extended wear lens for correction of aphakia was investigated in 177 eyes [19].
• Pediculosis among rural school children in Kelang, Selangor, Malaysia and their susceptibility to malathion, carbaryl, perigen and kerosene [20].

Biological context of S-3151

• The homeostatic maintenance of the "modification threshold" for inducing long-term potentiation (LTP) is a fundamental feature of the Bienenstock, Cooper, and Munro (BCM) model of synaptic plasticity [21].
• The Bienenstock, Cooper, and Munro (BCM) theory of synaptic plasticity has successfully reproduced the development of orientation selectivity and ocular dominance in kitten visual cortex in normal, as well as deprived, visual environments [22].
• In contrast, for the epidermal growth factor receptor (T. Hunter, N. Ling, and J. A. Cooper, Nature [London] 311:480-483, 1984) and pp60src (K. L. Gould, J. R. Woodgett, J. A. Cooper, J. E. Buss, D. Shalloway, and T. Hunter, Cell 42:849-857, 1985), the sites of protein kinase C phosphorylation are amino-terminal to the kinase domain [23].
• The same mutation in a v-Ha-ras gene reduces the affinity of p21 for guanine nucleotides (L.A. Feig, B. Pan, T.M. Roberts, and G.M. Cooper, Proc. Natl. Acad. Sci. USA 83:4607-4611, 1986) [24].
• Recordings from areas 17 and 18 of the intact visual cortex showed that up to 20 degrees of the ipsilateral visual field is also represented and that the ipsilateral representation is organized as in a Boston Siamese cat (Hubel and Wiesel, 1971; Shatz, 1977; Cooper and Blasdel, 1980) or a heterozygous albino cat (Leventhal et al., 1985b) [25].

Anatomical context of S-3151

• The Mr 150,000 sgp has a similar chemical structure to the sulphated glycoprotein, C, synthesized and laid down in Reichert's membrane by mouse embryo parietal endoderm cells (Hogan, B. L.M., A. Taylor, and A.R. Cooper, 1982, Dev. Biol., 90:210-214) [26].
• We have shown previously (McFarlane and Cooper, 1992) that neonatal superior cervical ganglia (SCG) neurons express three voltage-gated K currents: a noninactivating delayed-rectifier type current (IK), a rapidly inactivating A-current (IAf), and a slowly inactivating A-current (IAs) [27].
• Pandinus imperator scorpion venom blocks voltage-gated potassium channels in nerve fibers [28].
• We have examined the effects of venom from the scorpion Pandinus imperator on the membrane currents of voltage-clamped frog myelinated nerve fibers using the Vaseline-gap method [28].
• The weak immunologic degranulation of rat basophil leukemia cells by dimyristoylphosphatidylcholine membrane targets at 37 degrees C can be attributed to a weak binding of anti-dinitrophenyl IgE to these membranes (Balakrishnan, K., Hsu, F. J., Cooper, A. D., and McConnell, H. M. (1982) J. Biol. Chem. 257, 6427-6433) [29].

Associations of S-3151 with other chemical compounds

• Ezrin was then found to be homologous to p81 and to be phosphorylated on tyrosine in response to EGF (Gould, K. L., J. A. Cooper, A. Bretscher, and T. Hunter. 1986. J. Cell Biol. 102:660-669) [30].
• The only crystal structure reported for acetate kinase is the homodimeric enzyme from Methanosarcina thermophila containing ADP and sulfate in the active site (Buss, K. A., Cooper, D. C., Ingram-Smith, C., Ferry, J. G., Sanders, D. A., and Hasson, M. S. (2001) J. Bacteriol. 193, 680-686) [31].
• We have shown previously that several conserved lysine residues (positions 68, 71, 80, and 104) within the collagenous domain of adiponectin are modified by hydroxylation and glycosylation (Wang, Y., Xu, A., Knight, C., Xu, L. Y., and Cooper, G. J. (2002) J. Biol. Chem. 277, 19521-19529) [32].
• The lithium loading dose method developed by Cooper and associates resulted in achievement of therapeutic concentrations in 29 of 30 psychiatric inpatients [33].
• RESULTS: We have identified one of the soluble fluorescent components of the scorpions Centuroides vittatus and Pandinus imperator as beta-carboline - a tryptophan derivative that has previously been identified by hydrolysis and oxidation of lens protein [34].

Gene context of S-3151

• CSK is recruited to these sites of c-Src activation via its SH2 and SH3 domains and is then in a position to downregulate c-Src activity (B. W. Howell and J. A. Cooper, Mol. Cell. Biol. 14:5402-5411, 1994) [35].
• Deletion of Dab2 induces a urinary increase in specific plasma proteins such as vitamin D binding protein and retinol binding protein (Morris SM, Tallquist MD, Rock CO, and Cooper JA. EMBO J 21: 1555-1564, 2002) [36].
• Except for five single base substitutions, our results indicate that the Cooper, Q3932, and LA strains share the same tk sequence [37].
• Identification of filamin C as a new physiological substrate of PKBalpha using KESTREL [38].
• Exploitation of KESTREL to identify NDRG family members as physiological substrates for SGK1 and GSK3 [39].

Analytical, diagnostic and therapeutic context of S-3151

• Protamine 1 gene sequence from the primate Saguinus imperator isolated with PCR using consensus oligonucleotides [40].
• We show that single electron tunneling devices such as the Cooper-pair box or double quantum dot can be sensitive to the zero-point fluctuation of a single trapping center hybridized with a Fermi sea [41].
• RESEARCH DESIGN AND METHODS: In this cohort study we examined 2,333 men with documented diabetes (mean age 49.4 years) that had baseline 5-min HRR measurement following maximal exercise (heart rate(peak) - heart rate(5 min of recovery)) at The Cooper Clinic, Dallas, TX [42].
• This was first proposed by Tilney [Tilney, L. G., et al. (1983) J. Cell Biol. 97, 112-124] and demonstrated by Pollard and Cooper [(1984) Biochemistry 23, 6631-6641] by electron microscopy [43].
• The current study included 10,746 adults who were 22-96 years of age, were free of known CHD, and had their CAC quantified by electron-beam tomography at baseline as part of a preventive medical examination at the Cooper Clinic (Dallas, Texas) during 1995-2000 [44].

References