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Gene Review

SPCS1  -  signal peptidase complex subunit 1 homolog...

Homo sapiens

Synonyms: HSPC033, Microsomal signal peptidase 12 kDa subunit, SPC1, SPC12, SPase 12 kDa subunit, ...
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Psychiatry related information on SPCS1

  • The SPCS may be useful in identifying reinforcers, promoting happiness, analyzing task and staff effects, and clarifying the relationship of stimulus preference to psychopathology [1].

High impact information on SPCS1

  • Furthermore, stress-activated MAPK, Spc1 (also known as StyI or Phh1), induces the expression and phosphorylation of the Srr2 protein [2].
  • Spc1 activation upon oxidative stress is severely impaired in the Deltampr1 mutant as well as in the mpr1HQ strain, in which the putative phosphorylation site Mpr1-His221 is substituted with glutamine [3].
  • We have determined the cDNA sequence of the remaining 12-kDa subunit (SPC12) as well as the membrane topologies of SPC12 and SPC25 in rough microsomes [4].
  • Removal of the CRR resulted in a broadening of the enzyme's pH range, a shift of K(0.5) for Ca(2+), and a shorter enzymatic half-life when compared to the longer form, which suggest that the CRR of hSPC1 may help in stabilizing the enzyme's proteolytic activity [5].

Biological context of SPCS1

  • In response to oxidative stress, Mpr1 binds to the Mcs4 response regulator that functions upstream of the Spc1 cascade, suggesting that Mcs4 is a cognate response regulator for Mpr1 [3].

Other interactions of SPCS1

  • Therefore, SPC12 and SPC25 are likely to be involved in processes other than the enzymatic cleavage of the signal sequence [4].


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