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Gene Review

SPCS2  -  signal peptidase complex subunit 2 homolog...

Homo sapiens

Synonyms: KIAA0102, Microsomal signal peptidase 25 kDa subunit, SPC25, SPase 25 kDa subunit, Signal peptidase complex subunit 2
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High impact information on SPCS2


Biological context of SPCS2


Other interactions of SPCS2

  • Therefore, SPC12 and SPC25 are likely to be involved in processes other than the enzymatic cleavage of the signal sequence [3].

Analytical, diagnostic and therapeutic context of SPCS2

  • A minicolumn filled with Sephadex SPC-25 microbeads was used to achieve separation of both analytes before detection in a flow-through cell filled with the same resin [5].


  1. Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites. DeLuca, J.G., Dong, Y., Hergert, P., Strauss, J., Hickey, J.M., Salmon, E.D., McEwen, B.F. Mol. Biol. Cell (2005) [Pubmed]
  2. Identification of two novel components of the human NDC80 kinetochore complex. Bharadwaj, R., Qi, W., Yu, H. J. Biol. Chem. (2004) [Pubmed]
  3. Membrane topology of the 12- and the 25-kDa subunits of the mammalian signal peptidase complex. Kalies, K.U., Hartmann, E. J. Biol. Chem. (1996) [Pubmed]
  4. cDNA-derived primary structure of the 25-kDa subunit of canine microsomal signal peptidase complex. Greenburg, G., Blobel, G. J. Biol. Chem. (1994) [Pubmed]
  5. Multicommuted flow-through fluorescence optosensor for determination of furosemide and triamterene. Llorent-Martínez, E.J., Ortega-Barrales, P., Molina-Díaz, A. Analytical and bioanalytical chemistry. (2005) [Pubmed]
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