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Gene Review

MACROD1  -  MACRO domain containing 1

Homo sapiens

Synonyms: LRP16, MACRO domain-containing protein 1, O-acetyl-ADP-ribose deacetylase MACROD1, Protein LRP16
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Disease relevance of LRP16


High impact information on LRP16


Analytical, diagnostic and therapeutic context of LRP16

  • The expression level of LRP16 mRNA induced by 17beta-E(2) was determined by Northern blot analysis [3].


  1. Mechanism of transcriptional regulation of LRP16 gene expression by 17-beta estradiol in MCF-7 human breast cancer cells. Zhao, Y.L., Han, W.D., Li, Q., Mu, Y.M., Lu, X.C., Yu, L., Song, H.J., Li, X., Lu, J.M., Pan, C.Y. J. Mol. Endocrinol. (2005) [Pubmed]
  2. The single-macro domain protein LRP16 is an essential cofactor of androgen receptor. Yang, J., Zhao, Y.L., Wu, Z.Q., Si, Y.L., Meng, Y.G., Fu, X.B., Mu, Y.M., Han, W.D. Endocr. Relat. Cancer (2009) [Pubmed]
  3. Up-regulation of LRP16 mRNA by 17beta-estradiol through activation of estrogen receptor alpha (ERalpha), but not ERbeta, and promotion of human breast cancer MCF-7 cell proliferation: a preliminary report. Han, W.D., Mu, Y.M., Lu, X.C., Xu, Z.M., Li, X.J., Yu, L., Song, H.J., Li, M., Lu, J.M., Zhao, Y.L., Pan, C.Y. Endocr. Relat. Cancer (2003) [Pubmed]
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