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Gene Review

Dpp6  -  dipeptidylpeptidase 6

Rattus norvegicus

Synonyms: DPP VI, DPPX, Dipeptidyl aminopeptidase-like protein 6, Dipeptidyl aminopeptidase-related protein, Dipeptidyl peptidase 6, ...
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High impact information on Dpp6

  • We purified A-type K(+) channel complexes from rat brain membranes and found that DPPX, a protein of unknown function that is structurally related to the dipeptidyl aminopeptidase and cell adhesion protein CD26, is a novel component of A-type K(+) channels [1].
  • The membrane topology of DPPX-S and -L is similar to that of other transmembrane peptidases, and DPPX-S share approximately 30% identity and 50% similarity with reported yeast and rat liver dipeptidyl aminopeptidase amino acid sequences, suggesting that DPPX is a member of the dipeptidyl aminopeptidase family [2].
  • Seven genes, lecithin:cholesterol acyltransferase, dipeptidyl aminopeptidase related protein, phospholipase C delta 4, plasma membrane Ca2+-ATPase isoform 2, G-protein GO alpha subunit, GABA transporter 3, and neuroendrocrine protein 7B2 were down-regulated greater than 50% in SCI tissue [3].


  1. The CD26-related dipeptidyl aminopeptidase-like protein DPPX is a critical component of neuronal A-type K+ channels. Nadal, M.S., Ozaita, A., Amarillo, Y., Vega-Saenz de Miera, E., Ma, Y., Mo, W., Goldberg, E.M., Misumi, Y., Ikehara, Y., Neubert, T.A., Rudy, B. Neuron (2003) [Pubmed]
  2. Differential expression of two distinct forms of mRNA encoding members of a dipeptidyl aminopeptidase family. Wada, K., Yokotani, N., Hunter, C., Doi, K., Wenthold, R.J., Shimasaki, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  3. Analysis of gene expression following spinal cord injury in rat using complementary DNA microarray. Tachibana, T., Noguchi, K., Ruda, M.A. Neurosci. Lett. (2002) [Pubmed]
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