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Plcd1  -  phospholipase C, delta 1

Rattus norvegicus

Synonyms: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1, PLC-III, PLC-delta-1, Phosphoinositide phospholipase C-delta-1, Phospholipase C-III, ...
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Disease relevance of Plcd1


Psychiatry related information on Plcd1

  • Western blot analysis using a specific antibody for PLC-delta showed that the concentration of PLC-delta protein was significantly higher in the cytosolic fraction of Alzheimer disease cortical tissue than in control brains [6].

High impact information on Plcd1


Biological context of Plcd1


Anatomical context of Plcd1


Associations of Plcd1 with chemical compounds


Other interactions of Plcd1


Analytical, diagnostic and therapeutic context of Plcd1

  • Western blot analysis and immunocytochemical staining showed that PLC delta 4 is dominantly present in nucleus [13].
  • Immunofluorescence techniques were used to investigate the subcellular localization of two PLC isozymes (PLC-gamma and PLC-delta) in normal and simian virus 40-transformed REF52 cells to determine (i) if PLC colocalizes with alpha-PKC and (ii) if PLC isozyme distribution is sensitive to transformation [25].
  • In this study, interaction sites on TGII for the alpha 1B-AR were identified using a peptide approach and site-directed mutagenesis, including in vivo reconstitution of TGIIs with the alpha 1B-AR and PLC-delta 1 [16].
  • Expression of PLC-delta in the neoplasms was not detected by northern blot analysis, and a low level of expression was detected by immunoblot analysis, although PLC-delta expression was apparent in the non-neoplastic colon mucosae of MAM acetate-treated rats as well as in the colon mucosae of control rats [5].
  • Expression, characterization, and crystallization of the catalytic core of rat phosphatidylinositide-specific phospholipase C delta 1 [26].


  1. Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain. Ferguson, K.M., Lemmon, M.A., Schlessinger, J., Sigler, P.B. Cell (1995) [Pubmed]
  2. Attenuation of renomedullary phospholipase C isozyme, PLC-delta 1, in spontaneously hypertensive rats. Lee, K.H., Cho, Y.J., Cha, S.H., Endou, H. Biochem. Mol. Biol. Int. (1997) [Pubmed]
  3. Expression and characterization of an inositol 1,4,5-trisphosphate binding domain of phosphatidylinositol-specific phospholipase C-delta 1. Yagisawa, H., Hirata, M., Kanematsu, T., Watanabe, Y., Ozaki, S., Sakuma, K., Tanaka, H., Yabuta, N., Kamata, H., Hirata, H. J. Biol. Chem. (1994) [Pubmed]
  4. Molecular cloning, splice variants, expression, and purification of phospholipase C-delta 4. Lee, S.B., Rhee, S.G. J. Biol. Chem. (1996) [Pubmed]
  5. Reduced expression of phospholipase C-delta, a signal-transducing enzyme, in rat colon neoplasms induced by methylazoxymethanol acetate. Yoshimi, N., Wang, A., Makita, H., Suzui, M., Mori, H., Okano, Y., Banno, Y., Nozawa, Y. Mol. Carcinog. (1994) [Pubmed]
  6. Alteration of phospholipase C-delta protein level and specific activity in Alzheimer's disease. Shimohama, S., Fujimoto, S., Matsushima, H., Takenawa, T., Taniguchi, T., Perry, G., Whitehouse, P.J., Kimura, J. J. Neurochem. (1995) [Pubmed]
  7. Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta. Essen, L.O., Perisic, O., Cheung, R., Katan, M., Williams, R.L. Nature (1996) [Pubmed]
  8. Differential regulation of renal phospholipase C isoforms by catecholamines. Yu, P.Y., Asico, L.D., Eisner, G.M., Jose, P.A. J. Clin. Invest. (1995) [Pubmed]
  9. A dual functional signal mediator showing RhoGAP and phospholipase C-delta stimulating activities. Homma, Y., Emori, Y. EMBO J. (1995) [Pubmed]
  10. C2 domain conformational changes in phospholipase C-delta 1. Grobler, J.A., Essen, L.O., Williams, R.L., Hurley, J.H. Nat. Struct. Biol. (1996) [Pubmed]
  11. Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Lemmon, M.A., Ferguson, K.M., O'Brien, R., Sigler, P.B., Schlessinger, J. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  12. Assignment of the rat phospholipase C-delta1 gene (Plcd1) to rat chromosome band 8q32 by fluorescence in situ hybridization and radiation hybrid mapping. Kim, H., Kang, Y.H., Lee, K.H., Lee, W.K., Park, S.H. Cytogenet. Cell Genet. (2001) [Pubmed]
  13. A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. Liu, N., Fukami, K., Yu, H., Takenawa, T. J. Biol. Chem. (1996) [Pubmed]
  14. Nerve growth factor stimulates phosphorylation of phospholipase C-gamma in PC12 cells. Kim, U.H., Fink, D., Kim, H.S., Park, D.J., Contreras, M.L., Guroff, G., Rhee, S.G. J. Biol. Chem. (1991) [Pubmed]
  15. Phospholipase C beta 2 in vascular smooth muscle. LaBelle, E.F., Polyák, F. J. Cell. Physiol. (1996) [Pubmed]
  16. Alpha 1B-adrenoceptor interacts with multiple sites of transglutaminase II: characteristics of the interaction in binding and activation. Feng, J.F., Gray, C.D., Im, M.J. Biochemistry (1999) [Pubmed]
  17. Identification of three phospholipase C isotypes expressed in rat olfactory epithelium. Bruch, R.C., Abogadie, F.C., Farbman, A.I. Neuroreport (1995) [Pubmed]
  18. Fuel and hormone regulation of phospholipase C beta 1 and delta 1 overexpressed in RINm5F pancreatic beta cells. Kelley, G.G., Ondrako, J.M., Reks, S.E. Mol. Cell. Endocrinol. (2001) [Pubmed]
  19. Putative inositol 1,4,5-trisphosphate binding proteins in rat brain cytosol. Kanematsu, T., Takeya, H., Watanabe, Y., Ozaki, S., Yoshida, M., Koga, T., Iwanaga, S., Hirata, M. J. Biol. Chem. (1992) [Pubmed]
  20. Phosphorylation of phospholipase C-gamma by cAMP-dependent protein kinase. Kim, U.H., Kim, J.W., Rhee, S.G. J. Biol. Chem. (1989) [Pubmed]
  21. Phospholipase C-gamma 1 associates with viral and cellular src kinases. Nakanishi, O., Shibasaki, F., Hidaka, M., Homma, Y., Takenawa, T. J. Biol. Chem. (1993) [Pubmed]
  22. Angiotensin II stimulates tyrosine phosphorylation of phospholipase C-gamma 1 in vascular smooth muscle cells. Marrero, M.B., Paxton, W.G., Duff, J.L., Berk, B.C., Bernstein, K.E. J. Biol. Chem. (1994) [Pubmed]
  23. Modulation of intracellular Ca(2+) via alpha(1B)-adrenoreceptor signaling molecules, G alpha(h) (transglutaminase II) and phospholipase C-delta 1. Kang, S.K., Kim, D.K., Damron, D.S., Baek, K.J., Im, M.J. Biochem. Biophys. Res. Commun. (2002) [Pubmed]
  24. Phosphatidylinositol 4-OH kinase is a downstream target of neuronal calcium sensor-1 in enhancing exocytosis in neuroendocrine cells. Rajebhosale, M., Greenwood, S., Vidugiriene, J., Jeromin, A., Hilfiker, S. J. Biol. Chem. (2003) [Pubmed]
  25. Immunocytochemical localization of phospholipase C-gamma in rat embryo fibroblasts. McBride, K., Rhee, S.G., Jaken, S. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  26. Expression, characterization, and crystallization of the catalytic core of rat phosphatidylinositide-specific phospholipase C delta 1. Grobler, J.A., Hurley, J.H. Protein Sci. (1996) [Pubmed]
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