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Gene Review

DPP6  -  dipeptidyl-peptidase 6

Homo sapiens

Synonyms: DPP VI, DPPX, Dipeptidyl aminopeptidase-like protein 6, Dipeptidyl aminopeptidase-related protein, Dipeptidyl peptidase 6, ...
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Disease relevance of DPP6


High impact information on DPP6

  • To dissect the structural determinants of these integral accessory proteins, we constructed chimeras of DPPX, DPP10, and DPPIV lacking the extracellular domain [5].
  • The dimeric structure of DPPX is highly homologous to the related protein DPP-IV [6].
  • However, the arrangement of residues is inconsistent with that of canonical serine proteases and DPPX is unlikely to function as a protease (dipeptidyl aminopeptidase) [6].
  • Comparison of the active sites of DPPX and DPP-IV reveals loss of the catalytic serine residue but the presence of an additional serine near the "active" site [6].
  • Here, we review (1) the physiological and genetic properties of ISA, 2 the molecular mechanisms of Kv4 inactivation and its remodeling by a family of soluble calcium-binding proteins (KChIPs) and a membrane-bound dipeptidase-like protein (DPPX), and (3) the modulation of Kv4 channels by protein phosphorylation [7].

Biological context of DPP6

  • Co-expression of DPPX in addition to Kv4.3 and KChIP2a produced similar current kinetics as in human ventricular myocytes [8].

Anatomical context of DPP6

  • In addition, the qualitative stability/metabolism pattern of TPT in liver microsomes prepared from various groups of rats (normal rats, UN-ARF rats, rats treated with DPPX, and UN-ARF rats treated with DPPX) was found to be similar [9].

Associations of DPP6 with chemical compounds

  • The serine residue is also replaced in DPP6, which lacks peptidase activity [10].
  • Cathepsin B/L-, elastase-, tryptase-, trypsin-, and dipeptidyl peptidase IV-like activities in GCF samples were determined by fluorimetric assay with peptidyl derivatives of 7-amino-4-trifluoromethyl coumarin [11].
  • In summary, using a pharmacokinetic tool as a surrogate, it has been shown that the pharmacokinetic disposition of TPT improved considerably upon treatment with DPPX, a selective adenosine A1 antagonist [9].
  • Cathepsin B/L-like activity was determined with Bz-Val-Lys-Lys-Arg-AFC, elastase-like activity with MeOSuc-Ala-Ala-Pro-Val-AFC, tryptase-like activity with Z-Ala-Ala-Lys-AFC, trypsin-like activity with Z-Gly-Gly-Arg-AFC and dipeptidyl peptidase IV-like activity with Ala-Pro-AFC [12].
  • The disposition of TPT did not normalize in UN-ARF rats when treated with caffeine, a non-selective adenosine A1 receptor antagonist, whereas the selective adenosine A1 receptor antagonist (1,3-dipropyl-8-phenylxanthine, DPPX) normalized TPT pharmacokinetic disposition by improving renal function [9].

Other interactions of DPP6

  • Dipeptidyl peptidase 10 (DPP10) shares with DPP6 a high amino acid identity, lack of enzymatic activity, and expression predominantly in the brain [13].
  • In the present study, we describe the cloning of DPP10, a novel 796-amino-acid protein, with significant sequence identity to DPP4 (32%) and DPP6 (51%) respectively [10].

Analytical, diagnostic and therapeutic context of DPP6

  • With quantitative real-time RT-PCR strong mRNA expression of DPPX was detected in human ventricles and was verified at the protein level in human but not in rat heart by a DPPX-specific antibody [8].


  1. Cathepsin B/L-, elastase-, tryptase-, trypsin- and dipeptidyl peptidase IV-like activities in gingival crevicular fluid: correlation with clinical parameters in untreated chronic periodontitis patients. Eley, B.M., Cox, S.W. J. Periodont. Res. (1992) [Pubmed]
  2. Quaternary benzo[c]phenanthridine alkaloids as inhibitors of dipeptidyl peptidase IV-like activity baring enzymes in human blood plasma and glioma cell lines. Sedo, A., Malík, R., Vicar, J., Simánek, V., Ulrichová, J. Physiological research / Academia Scientiarum Bohemoslovaca. (2003) [Pubmed]
  3. Detection of cathepsin B- and L-, elastase-, tryptase-, trypsin-, and dipeptidyl peptidase IV-like activities in crevicular fluid from gingivitis and periodontitis patients with peptidyl derivatives of 7-amino-4-trifluoromethyl coumarin. Cox, S.W., Eley, B.M. J. Periodont. Res. (1989) [Pubmed]
  4. Ophidian envenomation strategies and the role of purines. Aird, S.D. Toxicon (2002) [Pubmed]
  5. DPP10 modulates Kv4-mediated A-type potassium channels. Zagha, E., Ozaita, A., Chang, S.Y., Nadal, M.S., Lin, U., Saganich, M.J., McCormack, T., Akinsanya, K.O., Qi, S.Y., Rudy, B. J. Biol. Chem. (2005) [Pubmed]
  6. Structure of a human A-type potassium channel interacting protein DPPX, a member of the dipeptidyl aminopeptidase family. Strop, P., Bankovich, A.J., Hansen, K.C., Garcia, K.C., Brunger, A.T. J. Mol. Biol. (2004) [Pubmed]
  7. Molecular physiology and modulation of somatodendritic A-type potassium channels. Jerng, H.H., Pfaffinger, P.J., Covarrubias, M. Mol. Cell. Neurosci. (2004) [Pubmed]
  8. Expression and function of dipeptidyl-aminopeptidase-like protein 6 as a putative beta-subunit of human cardiac transient outward current encoded by Kv4.3. Radicke, S., Cotella, D., Graf, E.M., Ravens, U., Wettwer, E. J. Physiol. (Lond.) (2005) [Pubmed]
  9. Altered intravenous pharmacokinetics of topotecan in rats with acute renal failure (ARF) induced by uranyl nitrate: Do adenosine A1 antagonists (selective/non-selective) normalize the altered topotecan kinetics in ARF? Mustafa, S., Venkatesh, P., Pasha, K., Mullangi, R., Srinivas, N.R. Xenobiotica (2006) [Pubmed]
  10. Cloning and characterization of dipeptidyl peptidase 10, a new member of an emerging subgroup of serine proteases. Qi, S.Y., Riviere, P.J., Trojnar, J., Junien, J.L., Akinsanya, K.O. Biochem. J. (2003) [Pubmed]
  11. Cathepsin B/L-, elastase-, tryptase-, trypsin- and dipeptidyl peptidase IV-like activities in gingival crevicular fluid. A comparison of levels before and after basic periodontal treatment of chronic periodontitis patients. Cox, S.W., Eley, B.M. Journal of clinical periodontology. (1992) [Pubmed]
  12. Correlation of gingival crevicular fluid proteases with clinical and radiological measurements of periodontal attachment loss. Eley, B.M., Cox, S.W. Journal of dentistry. (1992) [Pubmed]
  13. Modulation of Kv4.2 channel expression and gating by dipeptidyl peptidase 10 (DPP10). Jerng, H.H., Qian, Y., Pfaffinger, P.J. Biophys. J. (2004) [Pubmed]
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