Disease relevance of UL47

• The left border of the genomic inversion of pseudorabies virus contains genes homologous to the UL46 and UL47 genes of herpes simplex virus type 1, but no UL45 gene [1].
• The cellular protein actin was enriched in virions of mutants deficient in any of the tegument proteins UL47, UL49, or US3 [2].
• Composition of pseudorabies virus particles lacking tegument protein US3, UL47, or UL49 or envelope glycoprotein E [2].

High impact information on UL47

• In the case of the UL48 gene product, a specific increase in incorporation of a smaller isoform was observed after deletion of the UL47 or UL49 gene, whereas a larger isoform remained unaffected [2].
• Nuclear import and export signals for the bovine herpesvirus type 1 UL47 protein (VP8 or bUL47) have been described previously [3].
• The absence of UL47 from this position coincides with the localization of a UL47-homologous ORF within the unique short (U(S)) region of the ILTV genome (M. Wild, S. Cook, and M. Cochran, Virus Genes 12:107-116, 1996) [4].
• The primary structure of VP8 showed considerable homology with the product of the UL47 reading frame of herpes simplex virus type 1 [5].
• PrV UL46 and UL47 are transcribed into two 3' co-terminal messenger RNAs with early and late kinetics, respectively [1].

Other interactions of UL47

• Comparison of the PrV UL46 and UL47 protein sequences with their counterparts from alphaherpesviruses indicated a strong similarity [1].
• Moreover, our data indicate that the UL47 and UL48 proteins function independently during cell-to-cell spread and virus egress [6].

References